Evidence map›Paper›PMID 42176201›Full record

ArticleMikrochimica acta2026

Enhanced online preconcentration and enantioseparation of MOF-coated capillary electrochromatography for chiral derivatized aromatic amino acids.

Chengxi Liu, Dan Zhong, Li Qi, Xiangtai Zheng, Yang Long, Shihan Xiao, Danni Zhang, Zizhen Liu, Jing Wang, Wenjie Liu and 2 more

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chengxi Liu *Department of Anesthesiology, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Dan ZhongShanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai, 200444, P.R. China.
Li Qi *Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, 200444, P. R. China.
Xiangtai ZhengShanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, 200444, P. R. China.
Yang LongDepartment of Anesthesiology, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Shihan XiaoDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Danni ZhangDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Zizhen LiuDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Jing WangDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China.
Wenjie LiuDepartment of Anesthesiology, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China. 2021020001@usc.edu.cn.
Wei LiDepartment of Breast and Thyroid Surgery, The Second Affiliated Hospital, University of South China, Hengyang, 421001, P. R. China. liwei0712@usc.edu.cn.
Xiaodong SunShanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University, Shanghai, 200444, P. R. China. sunxiaodong_cpu@163.com.

Funding

he National Natural Science Foundation of China 82473880he Shanghai Science and Technology Innovation Foundation 23010500200the Hunan Clinical Research Center for Acute and Chronic Pain 2023SK4014the Key Project of Hunan Provincial Department of Education 24A0289the Key R&D Program of Hunan Provincial Natural Science Funds 2024JK2131the National Natural Science Foundation of China 82003705the Natural Science Foundation of Hunan Province for Young Researchers 2025JJ60589the Postdoctoral Fellowship Program of CPSF GZC20231528the Shanghai Science and Technology Innovation Foundation 23ZR1422700
6 · The paper itself

Abstract

Conventional enantioseparation approaches of aromatic amino acids (AAAs) commonly suffer from inherent limitations, including insufficient detection sensitivity, poor enantioselectivity, and inefficient analyte preconcentration, which severely restrict their application in trace-level determinations. We rationally designed a metal-organic framework (MOF)-modified capillary electrochromatography (CEC) system by integrating MIL-140 C as an efficient enrichment material and HQA-MOF as a high-performance chiral stationary phase. This integrated platform achieved up to 120-fold analyte enrichment and a low limit of detection (LOD) of 12.5 ng/mL, exhibiting significantly improved detection sensitivity, chiral resolution, and method reproducibility compared to traditional strategies. Method validation in spiked bovine serum albumin (BSA) samples demonstrated satisfactory recoveries ranging from 92.35% to 108.04%. The established MOF-CEC strategy provides a highly sensitive, selective, and scalable analytical tool for the precise chiral determination of trace Dansylated Aromatic Amino Acids (DNS-AAAs) in simulated biological samples.

Indexed as

Amino Acids, AromaticCapillary ElectrochromatographyMetal-Organic FrameworksAnimalsCattleLimit of DetectionReproducibility of ResultsSerum Albumin, BovineStereoisomerismAmino Acids, AromaticMetal-Organic FrameworksSerum Albumin, BovineAromatic amino acidsCapillary electrochromatographyEnantioseparationMetal-organic frameworksOn-line enrichment

Identifiers

PMID42176201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.