ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Palliative care involvement and use of critical care therapies in patients with advanced cancer: a multicenter retrospective cohort study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCancer is a leading cause of mortality worldwide, and a substantial proportion of patients with advanced disease require ICU admission, where decisions regarding critical care therapies are complex. Despite recommendations for early palliative care integration, its implementation in ICU settings remains limited.
aimTo evaluate the association between palliative care involvement and the use of critical care therapies among critically ill patients with advanced solid tumors and in-hospital mortality.
designMulticenter retrospective cohort study. SETTING AND
participantsWe included 292 adult patients with advanced solid tumors admitted to the ICU at three tertiary hospitals in Argentina between 2010 and 2024 who died during hospitalization. Patients were categorized according to palliative care involvement before or during ICU admission.
resultsOverall, 23% of patients (95% CI, 19-29) received palliative care, including 18% (95% CI, 13-22) prior to ICU admission. Use of critical care therapies was lower among patients receiving palliative care compared with those who did not (54% vs. 72%; p < 0.01). After inverse probability weighting, palliative care involvement remained independently associated with lower odds of receiving critical care therapies (adjusted OR, 0.46; 95% CI, 0.33-0.66; p < 0.01). Hospital length of stay was shorter in the palliative care group (adjusted IRR, 0.67; 95% CI, 0.57-0.78; p < 0.01).
conclusionsIn this multicenter cohort of critically ill patients with advanced solid tumors, palliative care involvement was independently associated with reduced use of critical care therapies (including invasive mechanical ventilation, dialysis, parenteral nutrition, or tracheostomy) and shorter hospital length of stay, supporting its role in facilitating goal-concordant care.
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