ArticleWorld journal of urology2026
Pre-laser intraoperative urine culture provides key microbiological information for postoperative infectious management after flexible ureteroscopy for renal stone disease: a prospective single-surgeon study.
Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative infectious complications remain a clinically relevant concern after flexible ureteroscopy (FURS), including in patients with negative preoperative bladder urine cultures (UCs). Microbiological discordance between bladder and upper urinary tract samples may contribute to under-recognition of infectious risk. We assessed the clinical value of systematic intraoperative UCs obtained at predefined stages of FURS.
methodsWe relied on a prospectively collected dataset of 238 consecutive FURS procedures for renal stone disease conducted by a single experienced surgeon performed (2023-2025). UCs were obtained preoperatively and intraoperatively at standardized time points, including bladder urine at the start of the procedure, renal pelvic urine before laser lithotripsy, and renal pelvic urine after lithotripsy. The primary endpoint was postoperative infectious complications, classified as any infection and severe infection (sepsis/septic shock according to international definitions). Associations between culture-positivity patterns and outcomes were evaluated using Fisher's exact test and univariable logistic regression.
resultsAmong 952 UCs analyzed, 79% were negative overall. A total of 136 patients (57.1%) had negative cultures at all sampling time points. De novo intraoperative culture positivity occurred in 7.1% of patients with negative preoperative UCs. Pre-laser intraoperative UC positivity was significantly associated with postoperative infectious complications, with rates of any infection and severe infection of 27% and 23%, respectively. In univariable analyses, pre-laser intraoperative positivity (either renal pelvic or bladder urine) was associated with an increased risk of any infection (OR 6.14, 95% CI 1.43-24.3; p = 0.01) and severe infection (OR 8.87, 95% CI 1.53-51.8; p = 0.011) in reference to the all negative UC group. In contrast, isolated preoperative or post-laser UC positivity was not significantly associated with infectious outcomes.
conclusionsIntraoperative UCs obtained before laser lithotripsy were significantly associated with postoperative infectious complications following FURS for renal stone disease. Preoperative bladder UCs alone showed limited ability to identify patients at increased infectious risk. As culture results become available 24-48 h after surgery, intraoperative pre-laser sampling may represent a valuable microbiological tool to guide timely, culture-informed antibiotic therapy in patients who develop postoperative infectious complications.
Indexed as
Identifiers
42176121What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.