Evidence map›Paper›PMID 42176104›Full record

ArticleJournal of assisted reproduction and genetics2026

Pregnancy and perinatal outcomes following PIEZO-ICSI with vitrified-warmed single blastocyst transfer: a retrospective cohort study.

Kenichiro Hiraoka, Miki Osugi, Moe Sato, Yuko Kamada, Hayata Nakajo, Toshio Sujino, Akira Komiya, Yurie Nako, Yuko Takayanagi, Makiko Tajima and 4 more

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Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Kenichiro HiraokaKameda IVF Clinic Makuhari, Chiba, Japan. ken.msn.hiraoka@gmail.com.
Miki OsugiKameda IVF Clinic Makuhari, Chiba, Japan.
Moe SatoKameda IVF Clinic Makuhari, Chiba, Japan.
Yuko KamadaKameda IVF Clinic Makuhari, Chiba, Japan.
Hayata NakajoKameda IVF Clinic Makuhari, Chiba, Japan.
Toshio SujinoKameda IVF Clinic Makuhari, Chiba, Japan.
Akira KomiyaKameda IVF Clinic Makuhari, Chiba, Japan.
Yurie NakoKameda IVF Clinic Makuhari, Chiba, Japan.
Yuko TakayanagiKameda IVF Clinic Makuhari, Chiba, Japan.
Makiko TajimaKameda IVF Clinic Makuhari, Chiba, Japan.
Tatsuyuki OgawaOmotesando ART Clinic, Tokyo, Japan.
Kumi OhuchiKameda Medical Center, Kamogawa, Japan.
Masaru HayashiKameda Medical Center, Kamogawa, Japan.
Kiyotaka KawaiKameda IVF Clinic Makuhari, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report pregnancy and perinatal outcomes following intracytoplasmic sperm injection using a piezo element (PIEZO-ICSI) in a large Japanese cohort undergoing vitrified-warmed single blastocyst transfer. Outcomes from conventional IVF cycles were included as a reference population sharing similar ovarian stimulation and embryo transfer protocols.

methodsThis study was a retrospective cohort study conducted in two fertility centers in Japan. A total of 1,822 PIEZO-ICSI cycles from 1,072 patients aged < 40 years at oocyte retrieval were included between June 2016 and August 2023. A reference population of 1,701 IVF cycles from 996 patients was included for context.

resultsIn the PIEZO-ICSI cohort, the clinical pregnancy rate was 49.9% (910/1,822) and the live birth rate was 38.7% (706/1,822). Among live births, the mean birth weight was 3,011.4 ± 467.9 g, mean gestational age was 38.59 ± 1.95 weeks, and congenital anomaly rate was 1.6% (11/706). These outcomes were comparable to the IVF reference population (clinical pregnancy rate 48.4%, live birth rate 37.9%, birth weight 3,022.8 ± 469.5 g, congenital anomaly rate 2.5%). The proportion of female infants was significantly higher in the PIEZO-ICSI group (53.2% vs. 43.4%; P < 0.001).

conclusionPIEZO-ICSI is associated with favorable pregnancy and perinatal outcomes in women aged < 40 years.

Indexed as

Embryo TransferFertilization in VitroSingle Embryo TransferSperm Injections, IntracytoplasmicAdultBirth RateCryopreservationFemaleHumansInfant, NewbornJapanLive BirthOocyte RetrievalOvulation InductionPregnancyPregnancy OutcomeHumansIn vitro fertilization (IVF)Perinatal outcomesPIEZO-ICSISex ratio

Identifiers

PMID42176104
PMCPMC13518730

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