ArticleJournal of neurology2026
Cerebrovascular risk factors impact on brain atrophy and DTI-ALPS decrease in neuromyelitis optica spectrum disorder.
Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy where disability is largely relapse-driven. Cerebrovascular risk factors (cVRFs) may exacerbate astrocytic and small-vessel injury. Therefore, we investigated their impact on MRI damage and disability in NMOSD.
methodsTwenty-eight aquaporin 4 immunoglobulin G-positive NMOSD patients and 56 age- and sex-matched healthy controls (HC) underwent 3T brain and cervical MRI, cVRF and neurological assessment, including the Expanded Disability Status Scale (EDSS). Brain T2-hyperintense white matter lesion volume (WMLV), normalized global and regional volumes, normal-appearing WM (NAWM) fractional anisotropy (FA) and mean diffusivity (MD), diffusion tensor imaging analysis along the perivascular spaces (DTI-ALPS) index, spinal cord lesion volume (SCLV) and normalized cross-sectional area (nCSA) were quantified.
resultscVRF were present in 57% of NMOSD and 39% of HC, with smoking being the most frequent (all FDR-p = 0.734). Compared to HC, NMOSD showed significantly higher brain WMLV and SCLV, lower normalized brain (NBV), and deep gray matter volume (nDGMV) (all FDR-p ≤ 0.030). Significant diagnosis × cVRF interactions were found for nDGMV and DTI-ALPS (all FDR-p ≤ 0.038). In NMOSD, higher EDSS significantly correlated with lower DTI-ALPS (r = - 0.47, FDR-p = 0.048) and higher SCLV (r = 0.54, FDR-p = 030). Moderation analysis revealed that cVRFs significantly amplified the association between DTI-ALPS and disability (FDR-p = 0.045).
conclusionscVRFs amplify CNS damage and the clinical impact of impaired neurofluid dynamics in NMOSD, suggesting convergent vascular and astrocytic injury.
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