Observational studyArchives of women's mental health2026
Relationship between hypertensive disorders of pregnancy and postpartum mood and anxiety symptoms: P4 study.
Observational study in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEvaluate the relationship between hypertensive disorders of pregnancy (HDP) and long-term mood and anxiety symptoms by (a) investigating prevalence at 5-years after HDP versus normotensive pregnancy (b) comparing longitudinal data 6-months, 2-years and 5-years postpartum.
methodsWomen were recruited 2013-2018 following singleton birth into an observational cohort and categorised into groups: normal blood pressure (NBP), gestational hypertension (GH) and preeclampsia (PE). Surveys measured prevalence and severity of symptoms using the following screening tools: Edinburgh Postnatal Depression Scale (EPDS > 12), 7-item Generalized Anxiety Disorder Scale (GAD-7 ≥ 10), and Posttraumatic Stress Diagnostic Scale (PDS/PDS-5 ≥ 28).
results5-years postpartum, 314 participants were surveyed (normotensive n = 238(76%), gestational hypertension n = 17(5%), Preeclampsia n = 59(19%)). Mood and anxiety symptoms (EPDS > 12, GAD-7 ≥ 10, or PDS-5 ≥ 28) were present in 10.8%. Women following preeclampsia had similar prevalence of mood and anxiety symptoms at 5-years compared to NBP (normotensive 10.1% vs. preeclampsia 10.2%, p = 0.20). More women recalled childbirth as traumatic after preeclampsia (normotensive 0.4% vs. preeclampsia 5.5%, p = 0.01). Significant predictors for mood and anxiety symptoms 5-years postpartum were mental illness history and significant stress in the preceding 12-months (p < 0.001 and p = 0.01). Longitudinal analysis found higher rates of mood and anxiety symptoms 5-years (10.8%) than at 2-years and 6-months (5.4% and 4.5% respectively, p < 0.001).
conclusionPrevalence of mood and anxiety symptoms increased over time, hypertensive disorders of pregnancy were not a contributing factor. Prior mental illness and recent life stressors were key predictors.
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