Evidence map›Paper›PMID 42176076›Full record

ArticleAIDS and behavior2026

Uptake of HIV Self-testing Among Adolescents and Young Adults in Nigeria: A Secondary Observational Analysis of a Stepped-Wedge, Cluster-Randomized Trial.

Kadija M Tahlil, Audrey E Pettifor, Daniel Westreich, Jessie K Edwards, Weiming Tang, Titi Gbajabiamila, Hong Xian, Ucheoma Nwaozuru, Suzanne Day, Sonam J Shah and 11 more

Abstract read
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Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kadija M TahlilDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Audrey E PettiforDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Daniel WestreichDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jessie K EdwardsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Weiming TangInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Titi GbajabiamilaClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Hong XianDepartment of Epidemiology and Biostatistics, College for Public Health and Social Justice, St. Louis University, St. Louis, MO, USA.
Ucheoma NwaozuruDepartment of Implementation Science, Wake Forest School of Medicine, Winston- Salem, NC, USA.
Suzanne DayDepartment of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sonam J ShahInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nora E RosenbergDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David OladeleClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Adesola Z MusaClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Lateef A BlessingClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Ponmile OgunjemiteClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Donaldson F ConserveDepartment of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Temitope OjoDivision of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Gbenga OgedegbeInstitute for Excellence in Health Equity, New York University Grossman School of Medicine, New York, NY, USA.
Oliver EzechiClinical Sciences Department, Nigerian Institute of Medical Research, Lagos, Nigeria.
Juliet IwelunmorDivision of Infectious Diseases, John T. Milliken Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Joseph D TuckerInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. jdtucker@med.unc.edu.ORCID http://orcid.org/0000-0003-2804-1181

Funding

Eunice Kennedy Shriver National Institute of Child Health and Human Development 4UH3HD096929-03Eunice Kennedy Shriver National Institute of Child Health and Human Development 7UG1HD113156-02National Institute of Allergy and Infectious Diseases K24AI143471National Institute of Allergy and Infectious Diseases T32AI007001
6 · The paper itself

Abstract

Adolescents and young adults (AYA) in Nigeria with increased HIV risk, such as those who engage in multiple sexual partnerships (i.e., more than one sexual partner within a specified period), transactional sex (i.e., exchange of money or gifts for sex), or needle-sharing (i.e., needles or other injection equipment are shared by multiple people), are eligible for pre-exposure prophylaxis (PrEP). One strategy that has the potential to reach PrEP-eligible AYA is HIV self-testing, which can expand existing HIV testing services and support differentiated PrEP programs. However, little is known about HIV self-testing in these AYA populations. We examined associations between these three high-risk behaviors and HIV self-testing. We analyzed data from Innovative Tools to Expand Youth-friendly HIV Self-Testing (I-TEST), a stepped-wedge trial examining the impact of a combination intervention package on HIV self-testing among AYA aged 14-24 years in Nigeria. We fit generalized linear models, with an identity link and a binomial error distribution, using generalized estimating equations. We generalized trial estimates to all AYA in Nigeria using a two-stage weighted approach. Of 1,429 participants, the median age was 20 years (IQR: 18-22), 50.3% were female, and 69.4% reported secondary school as their highest education level completed. AYA who engaged in transactional sex had higher HIV self-testing uptake (8.1% [4.8, 11.5]) than AYA with no history of transactional sex. There were no statistically significant differences in recent HIV self-testing uptake among AYA by sexual partnerships or needle-sharing history. The trial estimates were similar in the adjusted models. The estimates for the trial and generalized samples were in the same direction, except for AYA with two recent sexual partners. There was a high level of HIV self-testing uptake across all categories of sexual partnerships, transactional sex, and needle-sharing, with significantly higher uptake among those who engaged in transactional sex, indicating that HIV self-testing strategies are reaching these various AYA populations and the need to sustain access for these groups.

Indexed as

AdolescentsHIVHIV self-testingNigeriaYoung adults

Identifiers

PMID42176076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.