ArticleApplied microbiology and biotechnology2026
Calcium enhances hydrolytic and transfucosylation activities in α-L-fucosidase from Thermotoga maritima through catalytic loop stabilization: an MD simulation study.
Article in Applied microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
α-L-Fucosidases are versatile glycoside hydrolases capable of catalyzing both hydrolysis and transfucosylation reactions, making them valuable biocatalysts for the synthesis of fucosylated oligosaccharides (FucOS). However, transfucosylation efficiency is often limited by competing hydrolysis, and the factors governing this balance remain incompletely understood. In this study, we investigated the effect of divalent cations on the catalytic behavior of the α-L-fucosidase from Thermotoga maritima (FUC-Tm) by combining enzymatic assays with molecular dynamics (MD) simulations and binding energy analyses. Among the tested ions, Ca
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