ArticlePediatric radiology2026
Multiparametric MRI biomarkers in pediatric osteosarcoma: associations of ADC, necrosis, and tumor volume with histologic and clinical outcomes in a retrospective cohort study.
Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of response to neoadjuvant chemotherapy in pediatric osteosarcoma is challenging, as histologic evaluation of tumor necrosis is only available after surgical resection. Quantitative MRI parameters, including diffusion-weighted imaging (DWI)-derived apparent diffusion coefficient (ADC) values, tumor volume, and radiologic necrosis, may provide noninvasive information related to treatment response and outcomes.
objectiveTo evaluate quantitative MRI features before and after neoadjuvant chemotherapy in pediatric osteosarcoma and to investigate their associations with histologic response and clinical outcomes. MATERIALS AND
methodsThis retrospective single-center cohort study included 50 pediatric patients with histologically confirmed osteosarcoma (2014-2023) who underwent MRI with DWI at diagnosis and after neoadjuvant chemotherapy. Tumor volume, radiologic necrosis, and ADC parameters (minimum, mean, and maximum) were independently assessed by two musculoskeletal radiologists. Histologic response was graded using the Huvos system. Associations between imaging parameters and histologic response, survival outcomes, and relapse were evaluated using nonparametric and exploratory time-to-event analyses.
resultsFifty pediatric patients were included (mean age 13.2 years; 62% male), of whom 21% had metastatic disease at diagnosis. Pre-treatment ADC minimum differed between good and poor histologic responders (median 661.75 vs 851.0×10⁻⁶ mm
conclusionQuantitative MRI parameters demonstrate exploratory associations with histologic response and clinical outcomes in pediatric osteosarcoma, providing additional information when interpreted alongside conventional MRI features and clinical data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.