Evidence map›Paper›PMID 42176051›Full record

ReviewCurrent allergy and asthma reports2026

The Role of the Indoor Exposome in Food Allergy Development.

Jessica R Humphrey, Priscilla Mathai, Timothy P Moran, Michael D Kulis, Johanna M Smeekens

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica R HumphreyDepartment of Pediatrics, University of North Carolina School of Medicine, 116 Manning Dr, Mary Ellen Jones, Room 3302, Chapel Hill, NC, 27599, USA. jessh1@unc.edu.
Priscilla MathaiDepartment of Pediatrics, University of North Carolina School of Medicine, 116 Manning Dr, Mary Ellen Jones, Room 3302, Chapel Hill, NC, 27599, USA.
Timothy P MoranDepartment of Pediatrics, University of North Carolina School of Medicine, 116 Manning Dr, Mary Ellen Jones, Room 3302, Chapel Hill, NC, 27599, USA.
Michael D KulisDepartment of Pediatrics, University of North Carolina School of Medicine, 116 Manning Dr, Mary Ellen Jones, Room 3302, Chapel Hill, NC, 27599, USA.
Johanna M SmeekensDepartment of Pediatrics, University of North Carolina School of Medicine, 116 Manning Dr, Mary Ellen Jones, Room 3302, Chapel Hill, NC, 27599, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewDue to the rapid rise in the prevalence of food allergy, environmental exposures, in addition to genetic susceptibility, are likely contributors to allergic disease. In developed countries, individuals spend a substantial proportion of time indoors. Therefore, the indoor exposome provides a unique framework to examine factors driving the increase in the rates of food allergy. This review summarizes epidemiological and mechanistic evidence of the indoor exposome, consisting of the combined exposures to food antigens, microbes, and chemicals encountered in indoor environments during early life, and their influence on food allergy development. RECENT

findingsIndoor house dust contains detectable food allergens, which remain biologically active and may be linked to non-oral exposure, leading to allergic sensitization. In contrast, early-life exposures to diverse microbes and their products are associated with protection from allergic disease. Emerging evidence further demonstrates that indoor chemicals, including detergents, plasticizers, and pollutants, can disrupt epithelial barrier integrity or function as immune adjuvants, thus increasing susceptibility to food sensitization. Collectively, these findings highlight the indoor exposome as a complex and important determinant of food allergy risk. Improved understanding of how the indoor exposome influences food allergy development may inform future primary prevention or intervention strategies.

Indexed as

Air Pollution, IndoorEnvironmental ExposureExposomeFood HypersensitivityAllergensAnimalsDustHumansAllergensDustExposomeFood allergyHouse dustIndoor microbiomePeanut allergy

Identifiers

PMID42176051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.