Evidence map›Paper›PMID 42176041›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Short-term actions of arsenic trioxide on metabolic fluxes in the isolated perfused rat liver.

Nairana Mithieli de Queiroz Eskuarek Melo, Rosane Marina Peralta, Lívia Bracht, Adelar Bracht

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nairana Mithieli de Queiroz Eskuarek MeloDepartment of Biochemistry, State University of Maringá, 87020900, Maringá, PR, Brazil.
Rosane Marina PeraltaDepartment of Biochemistry, State University of Maringá, 87020900, Maringá, PR, Brazil.
Lívia BrachtDepartment of Biochemistry, State University of Maringá, 87020900, Maringá, PR, Brazil.
Adelar BrachtDepartment of Biochemistry, State University of Maringá, 87020900, Maringá, PR, Brazil. adebracht@uol.com.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arsenic trioxide has recently been approved for the treatment of acute promyelocytic leukemia, but it is also a highly toxic compound. The purpose of the present work was to obtain a general view about the acute effects of arsenic trioxide on liver metabolism using the isolated perfused rat liver, a system that preserves microcirculation and cell polarity. Hepatic lactate and alanine gluconeogenesis were inhibited by arsenic trioxide with IC

Indexed as

Arsenic TrioxideLiverOxidesAdenosine TriphosphateAnimalsGluconeogenesisGlycolysisIn Vitro TechniquesMaleRatsRats, WistarAdenosine TriphosphateArsenic TrioxideOxidesArsenic trioxide toxicityFructolysisGluconeogenesisGlycolysisPyruvate carboxylation

Identifiers

PMID42176041
PMCPMC13503440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.