ArticleFish physiology and biochemistry2026
Involvement of Pax6 in the transcriptional regulation of gnrh1 in the Asian stinging catfish Heteropneustes fossilis.
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gonadotropin-releasing hormone plays a crucial role in vertebrate reproduction through the hypothalamo-hypophyseal-gonadal axis. While its functional effects are well understood, the transcriptional regulation of gnrh1 remains poorly characterized in teleosts. This study investigates the promoter regulation of catfish gnrh1, i.e., cfgnrh1, in the brain of the Asian stinging catfish, Heteropneustes fossilis. To accomplish this, the 5'-upstream promoter fragments of cfgnrh1 were isolated and characterized using in silico motif analysis, luciferase reporter assays, chromatin immunoprecipitation, and site-directed mutagenesis. The results identified Pax6 as a key regulator of cfgnrh1 transcription. Immunolocalization of Pax6 and Gnrh in the preoptic area and hypothalamus of the H. fossilis brain indicates possible interaction. Polyethylenimine-mediated siRNA transient gene silencing of pax6 confirmed its regulatory importance, as evidenced by the downregulation of cfgnrh1. Collectively, these findings highlight and validate a clear transcriptional interaction between pax6 and cfgnrh1, emphasizing their significant roles in catfish reproduction.
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