Evidence map›Paper›PMID 42175902›Full record

ArticleFEMS yeast research2026

The yeast genome at 30: a blueprint written by a collaborative and consilient community.

Isak S Pretorius, John P Morrissey

Abstract read
In one paragraph

Article in FEMS yeast research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Isak S PretoriusThe Chancellery and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, NSW 2109, Australia.ORCID 0000-0001-9127-3175
John P MorrisseySchool of Microbiology, SUSFERM Fermentation Science research Centre, University College Cork, Cork, T12 K8AF, Ireland.ORCID 0000-0001-7960-2001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Completion of the Saccharomyces cerevisiae genome sequence three decades ago marked a defining moment in eukaryotic genomics. Beyond a technical milestone, it established a shared reference that transformed how yeast biology is studied, interpreted, and extended across disciplines. This Editorial revisits the yeast genome sequencing project with a focus on the scientific culture that enabled it: an extraordinarily collaborative community willing to coordinate effort, share resources, and collectively tackle biological complexity. That consilient culture proved essential in converting a static DNA sequence into a dynamic framework for discovery, enabling systematic exploration of gene function, cellular organization, and genome-scale biology. As this Special Collection celebrates the 30th anniversary of the yeast genome sequence, we reflect on how shared infrastructure, and collective ambition turned the genome sequences of three related lab strains (S288c and its derivatives FY1679 and AB972) into a lasting platform for innovation. Apart from enabling the field of population genomics and access to the vast genetic diversity of the species, these foundations have facilitated the synthesis and assembly of all 16 chromosomes of the same laboratory strain of S. cerevisiae, bringing the Sc2.0 project within reach of creating the first eukaryotic cell with a fully synthetic genome. This transition-from genome reading to genome writing-positions yeasts as powerful systems for iterative design-build-test-learn cycles and for reimagining genomes of other Saccharomyces and non-Saccharomyces strains (including those used in industry) as highly modifiable biological platforms.

Indexed as

Genome, FungalGenomicsSaccharomyces cerevisiaeconsiliencefunctional genomicsgenome engineeringgenome sequencingresearch collaborationSaccharomyces cerevisiaesynthetic genomicsyeast

Identifiers

PMID42175902
PMCPMC13251884

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.