Evidence map›Paper›PMID 42175849›Full record

ArticleElectrophoresis2026

A Consecutive Separation Strategy Using a 3D-Printed Microfluidic Chip to Achieve High-Purity White Blood Cells From Blood.

Haoyuan Gu, Feng Yang, Chushan Gao, Zheda Zhang, Longlong Wang, Yubin Zhou, Wenlai Tang, Xiang Gao, Shu Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Electrophoresis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoyuan GuSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Feng YangSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Chushan GaoSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Zheda ZhangSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Longlong WangSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Yubin ZhouSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Wenlai TangSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Xiang GaoSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.
Shu ZhuSchool of Electrical and Automation Engineering, and Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, Nanjing Normal University, Nanjing, China.

Funding

Key Research and Development Program of Jiangsu Province BE2022069-3The Basic Research Program of Jiangsu Province BK20250646The Fundings for Institute for Life and Health, Nanjing Drum Tower Hospital, Nanjing Normal University 211320B52603
6 · The paper itself

Abstract

Label-free and direct separation of white blood cells (WBCs) remains one of the major challenges in the field of efficient leukocyte separation. To address this challenge, we propose a WBC sorting strategy based on inertial microfluidics and 3D-printing technology, which employs a single inertial microfluidic chip to perform four consecutive high-throughput separation steps between red blood cells (RBCs) and WBCs. Specifically, the chip features a trapezoidal cross-section spiral channel to achieve size-dependent, stable spatial separation of cells along the inner and outer channels. After the conceptual design, the UV cured 3D printing technology is employed to fabricate the inertial chip and its fixture. Subsequently, mixed polystyrene microparticles are used as test objects to verify the sorting performance of the inertial chip, and the results indicate that the optimal separation flow rate is ∼1700

Indexed as

Cell SeparationLeukocytesMicrofluidic Analytical TechniquesPrinting, Three-DimensionalEquipment DesignErythrocytesHumansPolystyrenesPolystyrenes3D printingblood cellscell separationinertial microfluidics

Identifiers

PMID42175849
PMCPMC13480502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.