Evidence map›Paper›PMID 42175782›Full record

ArticleMolecular pain

CYP gene variants show preliminary evidence of association with patient-reported outcomes in active-duty service members with chronic pain.

Nathan L Tintle, Nathan A Ryder, Jason Westra, Dahee Wi, Sotaro Shimada, Nicholas Ieronimakis, Honor M McQuinn, Tyler J Snow, Ardith Z Doorenbos, Diane M Flynn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nathan L TintleSuperior Statistical Research, LLC, Sioux Center, IA, USA.ORCID 0000-0003-1447-9107
Nathan A RyderSuperior Statistical Research, LLC, Sioux Center, IA, USA.
Jason WestraSuperior Statistical Research, LLC, Sioux Center, IA, USA.
Dahee WiCollege of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Sotaro ShimadaCollege of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Nicholas IeronimakisDepartment of Clinical Investigation, Madigan Army Medical Center, Joint Base Lewis-McChord, Tacoma, WA, USA.
Honor M McQuinnPhysical Performance Service Line, Madigan Army Medical Center, Joint Base Lewis-McChord, Tacoma, WA, USA.
Tyler J SnowPhysical Performance Service Line, Madigan Army Medical Center, Joint Base Lewis-McChord, Tacoma, WA, USA.
Ardith Z DoorenbosCollege of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Diane M FlynnPhysical Performance Service Line, Madigan Army Medical Center, Joint Base Lewis-McChord, Tacoma, WA, USA.

Funding

Providing training in effective non-opioid options for the treatment of pain conditions.K24AT011995 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOORENBOS, ARDITH Z · 2021 to 2021
$324k
NCCIH NIH HHS K24 AT011995The U.S. Army Medical Research W81XWH-18-2-0023
6 · The paper itself

Abstract

Chronic pain is highly prevalent among active-duty service members (ADSMs) and contributes to substantial physical, psychological, and social burden. Genetic factors are recognized as central to pain susceptibility and treatment response. While few studies have examined the genes involved in cortisol synthesis, changes in the coding of cytochrome P450 (CYP) enzymes responsible for cortisol production have been implicated in chronic pain. We evaluated whether exonic variants in

Indexed as

Chronic PainGenetic VariationMilitary PersonnelPatient Reported Outcome MeasuresSteroid 17-alpha-HydroxylaseAdultFemaleHumansHydrocortisoneMalePolymorphism, Single NucleotideRandomized Controlled Trials as TopicSalivaYoung AdultHydrocortisoneSteroid 17-alpha-HydroxylaseChronic paincortisolgenesgenotypemilitary personnelpatient-reported outcomes

Identifiers

PMID42175782
PMCPMC13276232

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.