Evidence map›Paper›PMID 42175728›Full record

ArticleBioMed research international2026

Transcriptome-Based Analysis of Core Hub Genes Related to Cell Adhesion in Vero Cells.

Yiyang Fan, Yan Wang, Ruixiang Bi, Yapeng Zhao, Wanning Gao, Derong Zhang, Qiongyi Li, Jialin Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yiyang FanEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.ORCID https://orcid.org/0009-0004-9840-5192
Yan WangEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Ruixiang BiEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Yapeng ZhaoEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Wanning GaoEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Derong ZhangEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Qiongyi LiEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.
Jialin BaiEngineering Research Center for Key Technology and Industrialization of Cell-Based Vaccine, Ministry of Education, Northwest Minzu University, Lanzhou, China, xbmu.edu.cn.ORCID https://orcid.org/0000-0002-3505-1268

Funding

Lanzhou Talent Entrepreneurship and Innovation Project 2020-RC-85National Natural Science Foundation of China 31860696Northwest University for Nationalities 31920190003Special Fund Project for Basic Scientific Research Funds for the Central Universities 31920230154Special Fund Project for Basic Scientific Research Funds for the Central Universities 31920250002
6 · The paper itself

Abstract

The key to constructing suspension cell lines through genetic engineering technology lies in identifying the fundamental components and molecules involved in cell adhesion. In this study, differentially expressed genes between adherent and suspension Vero cells were analyzed using transcriptomics. The biological processes and pathways associated with these differentially expressed genes were examined through GSEA, GO, and KEGG enrichment analyses. The STRING database was employed to construct a protein-protein interaction (PPI) network, and core hub genes were identified using the MCODE and CytoHubba plugins in Cytoscape. Six core hub genes related to cell adhesion in Vero cells were identified: ITGA3, ITGA5, ITGB3, ITGB5, JUP, and PECAM1.

Indexed as

Cell AdhesionGene Expression ProfilingTranscriptomeAnimalsChlorocebus aethiopsGene Regulatory NetworksProtein Interaction MapsVero Cellsgenetic engineering techniquehub genePPIsuspension cell linesVero cells

Identifiers

PMID42175728
PMCPMC13197826

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.