Evidence map›Paper›PMID 42175670›Full record

ArticleClinical and translational medicine2026

Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy.

Linlin Zhu, Kejia Zhang, An Song, Weiye Zhao, Yongze Lin, Hao Xu, Zhichun Jin, Yan Wang, Shengnan Wu, Xueyu Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Linlin ZhuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Kejia ZhangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
An SongState Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.
Weiye ZhaoDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yongze LinDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Hao XuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Zhichun JinDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yan WangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Shengnan WuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Xueyu SunDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Heng GuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Ming LuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, China.
Hanwen ZhangKey Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.
Bin YanDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Funding

Jiangsu Province Capability Improvement Project through Science, Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit YJXYYJSDW4Jiangsu Provincial Medical Innovation Center CXZX202227National Natural Science Foundation of China 82371000National Natural Science Foundation of China 82571135
6 · The paper itself

Abstract

backgroundThe unpredictability of orthodontic tooth movement (OTM) and risks of root resorption stem from poorly understood mechanisms governing alveolar bone remodelling. Specifically, how macrophages transduce mechanical forces into osteoclastogenic signals remains elusive.

methodsOur integrated approach combined analyses at multiple levels: clinical analysis of human periodontal ligament (PDL) tissues via qPCR and immunofluorescence; in vivo functional assessment using murine OTM and fracture models with macrophage-specific knockouts (for Piezo1 and Z-DNA binding protein 1 (Zbp1), designated as Piezo1

resultsMechanical stress activated macrophage Piezo1, triggering Ca

conclusionThe Piezo1-ZBP1 axis constitutes a novel mechano-immune switch converting physical stress into inflammation and bone resorption. Pharmacological targeting of this axis offers a bidirectional therapeutic strategy for controlling orthodontic movement and enhancing bone repair.

Indexed as

Bone RemodelingIon ChannelsMacrophagesOsteogenesisRNA-Binding ProteinsAnimalsHumansMiceOsteoclastsPeriodontal LigamentStress, MechanicalTooth Movement TechniquesIon ChannelsPiezo1 protein, mouseRNA-Binding ProteinsZbp1 protein, mousemacrophagemechanotransductionorthodontic tooth movementosteoclastogenesisPiezo1ZBP1

Identifiers

PMID42175670
PMCPMC13239690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.