Evidence map›Paper›PMID 42175662›Full record

ArticleJournal of clinical periodontology2026

Salivary Microbiota From a Periodontitis Donor Is Associated With Altered IgA-Related Immune Features in Germ-Free Mice.

K Irie, T Azuma, R Minoshima, Y Mochida, R Yamada, K Nanashima, S Fuchida, N Kubota, K Tsukinoki, Y Sato and 2 more

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In one paragraph

Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

K IrieDepartment of Oral Health, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.ORCID https://orcid.org/0009-0008-1305-9876
T AzumaDepartment of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Japan.
R MinoshimaDepartment of Oral Health, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Y MochidaDepartment of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, Yokosuka, Japan.
R YamadaDepartment of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
K NanashimaDepartment of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, Yokosuka, Japan.
S FuchidaDepartment of Education Planning, Kanagawa Dental University, Yokosuka, Japan.
N KubotaDepartment of Diagnostic Pathology, Kanagawa Dental University, Yokosuka, Japan.
K TsukinokiDepartment of Environmental Pathology, Kanagawa Dental University, Yokosuka, Japan.
Y SatoDepartment of Molecular Hematopathology, Okayama University Graduate School of Health Sciences, Okayama, Japan.
T TomofujiDepartment of Community Oral Health, School of Dentistry, Asahi University, Mizuho, Japan.
T YamamotoDepartment of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, Yokosuka, Japan.

Funding

JSPS KAKENHI JP22K10316JSPS KAKENHI JP25K13327Takeda Science Foundation
6 · The paper itself

Abstract

aimThe oral microbiota has been implicated in mucosal immune regulation; however, its causal impact on salivary gland-associated immune features remains incompletely understood. In this proof-of-concept study, germ-free (GF) mice were colonised with salivary microbiota derived from either a periodontitis donor or a periodontally healthy donor, and IgA-associated immune readouts were evaluated across multiple compartments.

methodsGF mice were orally colonised with saliva-derived microbiota from a periodontitis patient or a periodontally healthy donor (or PBS). Total IgA in saliva, serum and faeces were quantified by ELISA. Cervical lymph nodes and blood were analysed by flow cytometry. Submandibular glands underwent histology and bulk RNA-seq.

resultsMice receiving microbiota from a periodontitis donor exhibited altered IgA levels in saliva, serum and faeces, increased faecal lipocalin-2, changes in innate immune cell distributions and increased CD138

conclusionsThese findings indicate that salivary microbiota from a periodontitis donor are associated with altered IgA-related immune features under GF conditions. While limited by the use of a single donor per group, this study provides proof-of-concept evidence supporting a potential role of oral microbiota in shaping salivary gland-associated immune characteristics.

Indexed as

Immunoglobulin AMicrobiotaPeriodontitisSalivaAnimalsFecesGerm-Free LifeHumansImmunity, InnateImmunity, MucosalMiceMice, Inbred C57BLSubmandibular GlandImmunoglobulin Amicrobiomemucosal immunityperiodontitissalivasystemic health

Identifiers

PMID42175662
PMCPMC13371819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.