Evidence map›Paper›PMID 42175615›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2026

Phenotyping healthcare use before pediatric-onset multiple sclerosis, including by sex and age: A matched cohort study.

Farahnaz Amini, Karl Everett, Feng Zhu, Ping Li, Kyla A McKay, Yinshan Zhao, Colleen J Maxwell, Ruth Ann Marrie, Helen Tremlett

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Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Farahnaz AminiFaculty of Medicine (Neurology), The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Karl EverettICES, Toronto, ON, Canada.
Feng ZhuFaculty of Medicine (Neurology), The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Ping LiICES, Toronto, ON, Canada.
Kyla A McKayDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Yinshan ZhaoFaculty of Medicine (Neurology), The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Colleen J MaxwellICES, Toronto, ON, Canada; Schools of Pharmacy and Public Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Ruth Ann MarrieDepartment of Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Nova Scotia Health, Halifax, NS, Canada.ORCID 0000-0002-1855-5595
Helen TremlettFaculty of Medicine (Neurology), The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5804-2535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about the prodrome in pediatric-onset multiple sclerosis (POMS), especially potential age and sex differences.

objectiveTo compare annual hospitalization and physician visit rates overall, and for physician visits, examine sex- and age-group (<12, 12-15, 16 to <18 years) differences, up to 18 years pre-first demyelinating event (pre-index) in 451 POMS and 1420 matched non-multiple sclerosis (MS) individuals.

methodUsing Ontario administrative data (1991-2020), we estimated rate ratios (RRs) by visit-related diagnosis, sex, and age using over-dispersed-Poisson models.

resultsThe POMS cohort showed elevated rates by year 1 pre-index ("year -1"), for ill-defined, other-health-contact, mental-, and respiratory-related hospitalizations (RRs ⩾ 3.6). Elevated physician visits began at year -14 for respiratory (RRs ⩾ 1.3), year -13 for endocrine (RRs ⩾ 2.4) and injury-related (RRs ⩾ 1.2), year -12 for ill-defined (RRs ⩾ 1.3), and year -11 for nervous system (RRs ⩾ 4.0) and mental-related (RRs ⩾ 2.0). Nervous system visits showed the largest sex-gap; males with (vs without) MS had elevated RRs from year -12 and females from year -6; both peaked the year pre-index (males: RR = 47.2; 95% confidence interval (CI): 17.3-128.3; females: RR = 17.0; 95% CI: 8.9-32.3). Among 12- to 15-year-olds, elevated rates were sustained for respiratory-related (from year -12, except year -5), injury-related, and ill-defined (from year -13); (all RR ⩾ 1.3), while findings were more sporadic in the other age groups.

conclusionFindings suggest prolonged, organ-specific healthcare use pre-POMS, with some sex- and age-related differences indicating pre-onset disease heterogeneity.

Indexed as

HospitalizationMultiple SclerosisPatient Acceptance of Health CareProdromal SymptomsAdolescentAge FactorsAge of OnsetChildCohort StudiesFemaleHumansMaleOntarioPhenotypeSex FactorsDemyelinating diseasehealthcare utilizationhospitalizationspediatric-onset multiple sclerosisphysician visitsprodromesex

Identifiers

PMID42175615
PMCPMC13385635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.