Evidence map›Paper›PMID 42175582›Full record

ReviewHead & neck2026

Surgical Treatment of Lateral Skull Base Tumors Extending to the Craniovertebral Junction.

Songbo Xue, Yang Zhao, Huiying Sun, Hanlin Chen, Yong Zhao, Xin Ding, Wanru Zheng, Fei Ren, Yiwei Zhao, Jiajing Tong and 5 more

Abstract readReview
In one paragraph

Review in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Songbo XueChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yang ZhaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
Huiying SunDepartment of Otorhinolaryngology-Head and Neck Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0002-1530-1311
Hanlin ChenChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID 0009-0001-7733-2455
Yong ZhaoChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xin DingChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Wanru ZhengChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.ORCID 0009-0006-7424-8211
Fei RenChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yiwei ZhaoChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jiajing TongChinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Yu ChenDepartment of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.ORCID 0000-0001-9795-9311
Zhiqiang GaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
Xu TianDepartment of Otorhinolaryngology-Head and Neck Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
Siyi CaiDepartment of Orthopedics, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.
Guodong FengDepartment of Otorhinolaryngology-Head and Neck Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing, China.

Funding

National High Level Hospital Clinical Research Funding 2022-PUMCH-B-095National High Level Hospital Clinical Research Funding 2025-PUMCH-D-005
6 · The paper itself

Abstract

objectiveTo evaluate the clinical manifestation, surgical strategies, and long-term outcomes of lateral skull base tumors extending to the craniovertebral junction (CVJ), with a focus on the infratemporal fossa approach (IFA) and individualized treatment options for cervical-occipital stability.

methodsThis retrospective cohort study included 12 patients with lateral skull base tumors extending to the CVJ who underwent surgical treatment between 2018 and 2024. Surgical resection via IFA (Type A, Type B, or Type A + Type B), with OCF performed when indicated by the extent of occipital condyle and C1-C2 resection.

resultsPrimary presenting symptoms included hearing loss (42%), headache (25%), and neck mass (17%). Imaging demonstrated that the original lateral skull base primary tumors often involved the temporal bone (92%), foramen magnum (92%), and jugular foramen (83%). Eight patients (67%) needed staged resections, while four (33%) patients underwent one-stage surgery. Occipitocervical fusion (OCF) was performed in five patients (42%), and the others received rigid collar or Halo-vest immobilization. Gross-total resection was accomplished in 11 patients (92%); one patient (8%) received palliative treatment. No recurrence was observed in these cases during a median follow-up of 45 months (range 6-78). Persistent posterior cranial nerve deficits occurred in 83% of the patients, and 33% developed transient aspiration pneumonia, both of which resolved with treatment.

conclusionIn a multidisciplinary context, the IFA, when combined with selective OCF, allows for complete resection and long-term tumor control of complex lateral skull base-CVJ tumors. This approach achieves both oncologic radicality and biomechanical stability.

Indexed as

Atlanto-Occipital JointSkull Base NeoplasmsAdultAgedCervical VertebraeFemaleHumansInfratemporal FossaMaleMiddle AgedOccipital BoneRetrospective StudiesSpinal FusionTreatment Outcomecraniovertebral junctioninfratemporal fossa approachlateral skull baseoccipitocervical fusion

Identifiers

PMID42175582
PMCPMC13332551

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.