ArticleMedicine2026
Acute tear-film disruption in treatment-naive acute anterior uveitis: A retrospective case-control study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to quantify the acute tear-film disruption in treatment-naive, 1st-onset noninfectious acute anterior uveitis (AAU) and identify independent and modifiable determinants. Retrospective case-control study enrolling 180 AAU eyes and 90 age-/sex-matched healthy controls. Same-day noninvasive tear breakup time (NIBUT), tear meniscus height, Schirmer-I and Ocular Surface Disease Index were extracted. Multivariable linear regression with bootstrap correction determined predictors of shorter NIBUT. Mean NIBUT was 4.7 seconds lower in AAU than controls (5.7 ± 1.5 seconds vs 10.4 ± 1.5 seconds; P < .001); 66% of AAU eyes versus 2% of controls had NIBUT ≤ 5 seconds. Tear meniscus height (-81 μm), Schirmer-I (-5.3 mm) and Ocular Surface Disease Index (+24 points) all worsened (P < .001). Independent reductions in NIBUT: anterior-chamber cells ≥ 2+ (-1.79 seconds), flare ≥ 3+ (-1.23 seconds), concomitant meibomian gland dysfunction (-0.96 seconds) and daily screen time > 8 hours (-0.59 seconds); adjusted R2 = 0.38, optimism-corrected R2 = 0.35. In this proof-of-concept study, 1st-onset AAU was associated with measurable tear-film destabilization driven by intraocular inflammatory load. While these findings suggest a potential role for early ocular-surface protection, effect sizes represent upper-bound estimates requiring confirmation in unscreened populations before routine clinical application.
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