Evidence map›Paper›PMID 42174754›Full record

Trial reportVirulence2026

Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial.

Yuanzhuo Chen, Jian Zhao, Jiangman Zhao, Qiyi Chen, Shi Dong, Shaohua Jia, Yi Zhao, Di Hao, Yangyang Yin, Sitong Lin and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuanzhuo ChenDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Jian ZhaoDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiangman ZhaoDepartment of Medicine, Shanghai Biotecan Pharmaceuticals Co., Ltd., Shanghai, China.ORCID 0000-0001-6572-6177
Qiyi ChenDepartment of Colorectal Disease, Intestinal Microenvironment Treatment Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Shi DongDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Shaohua JiaDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yi ZhaoDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Di HaoDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yangyang YinDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Sitong LinDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanqing ChenDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yugang ZhuangDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Hu PengDepartment of Emergency, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-2763-4893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Broad-spectrum antibiotics, essential for sepsis management in critically ill patients, cause significant gut dysbiosis. Restoring gut microbiota may improve outcomes, but the efficacy of interventions like fecal microbiota transplantation (FMT) and probiotics in this setting remains underexplored. This study aims to evaluate the feasibility and potential efficacy of FMT versus probiotics on gut microbiome restoration and inflammatory markers in critically ill, antibiotic-treated sepsis patients. In this single-center, prospective, exploratory pilot RCT, 40 sepsis patients were were randomized 2:1:1 to: Control (

Indexed as

Anti-Bacterial AgentsFecal Microbiota TransplantationGastrointestinal MicrobiomeProbioticsSepsisAgedDysbiosisFecesFemaleHumansMaleMiddle AgedPilot ProjectsProspective StudiesRNA, Ribosomal, 16STreatment OutcomeAnti-Bacterial AgentsRNA, Ribosomal, 16Sbroad-spectrum antibioticsfecal microbiota transplantationgut microbiotaprobioticsSepsis

Identifiers

PMID42174754
PMCPMC13203059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.