Evidence map›Paper›PMID 42174706›Full record

ReviewChinese medicine2026

Research progress of biological processing of traditional Chinese medicine:fermentation and sprouting.

Jia-Qi Shi, Xiao-Ting Wang, Jia-Li Tian, Yu Shi, Ya-Zhu Wang, Shu-Qing Tian, Fan Zhang, Hui Gao

Abstract readReview
In one paragraph

Review in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jia-Qi ShiSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Xiao-Ting WangSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Jia-Li TianSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Yu ShiSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Ya-Zhu WangSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Shu-Qing TianSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Fan ZhangSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China.
Hui GaoSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning Dalian, 116600, China. gaohuitcm@163.com.

Funding

Special Project for the Standardization of Traditional Chinese Medicine of the National Development and Reform Commission ZYBZH-Y-ZY-45Traditional Chinese Medicine Industry of the National Development and Reform Commission 201507004-03
6 · The paper itself

Abstract

aimThis paper presents a comprehensive review focusing on biological processing of traditional Chinese medicine. It reviews emerging modern fermentation technologies, as well as the two major aspects of biological processing of traditional Chinese medicine, fermentation processing and sprouting processing, covering key areas including their processing techniques, changes in TCM active ingredients, alterations in pharmacodynamic effects, and quality evaluation methods. The purpose of this review is to summarize the progress of TCM bioprocessing technologies, identify shortcomings in existing research, clarify the internal connections between different research areas, and ultimately provide comprehensive and reliable references for the further development of TCM bioprocessing research and its clinical application. MATERIALS AND

methodsPubMed, CNKI, Wanfang and CBM were systematically searched using keywords including "fermentation", "sprouting", "Arisaema cum Bile", and "Massa Medicata Fermentata". Relevant articles on TCM biological processing were screened and reviewed.

resultsBiological processing contributes significantly to optimizing TCM quality, potentiating efficacy and attenuating toxicity. Nevertheless, its industrialization is limited by unstable microbial strains and incomplete quality assessment systems, while systematic modern scientific elucidations are still lacking for its mechanisms and standardized application.

conclusionBiological processing of traditional Chinese medicine has fully exerted the clinical value of TCM and provided an important guarantee for the application of TCM. Future research should clarify its scientific connotation using modern indicators, improve its theoretical system, promote scaled and standardized development, and thereby advance the modernization and internationalization of TCM.

Indexed as

Biological processingFermentationProcessingSproutingTraditional Chinese medicine

Identifiers

PMID42174706
PMCPMC13195974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.