ArticleGenome biology2026
A reference genome for cultured Drosophila ovarian somatic cells enables studies of transposon and piRNA biology.
Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Retrovirus insertions in host transcripts trigger de novo piRNA immunity.The EMBO journal · 2026Article
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Abstract
backgroundAccurate reconstruction of repetitive genomic regions is essential to understand small RNA-mediated transposon silencing. In Drosophila ovarian somatic cells (OSCs), a primary model for nuclear PIWI-piRNA biology, reliance on the D. melanogaster reference (dm6) obscures cell-line-specific transposon insertions and the architecture of piRNA source loci.
resultsWe generated a highly contiguous de novo assembly of the OSC genome that reveals a transposon landscape diverging substantially from dm6. The assembly fully resolves the ∼700 kb flamenco locus, the principal piRNA cluster in OSCs, and yields a genome-wide map of transposon insertions. By integrating this assembly with functional genomics datasets, we define OSC piRNA source loci, show that cluster sequence composition determines transposon piRNA output, and demonstrate the widespread effects of Piwi on heterochromatin formation.
conclusionsThe OSC assembly establishes a precise genomic framework for interpreting piRNA and chromatin data in this model system. To enable community use of this resource for studies of transposon control and piRNA biology, we provide an integrated genome browser and data-sharing platform.
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