Evidence map›Paper›PMID 42174683›Full record

ReviewJournal of neuroinflammation2026

Regulator of G protein signaling 10: a critical regulator of chronic systemic inflammation in parkinson's disease.

Janna E Jernigan Posey, Kelly B Menees, Malú Gámez Tansey

Abstract readReview
In one paragraph

Review in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Janna E Jernigan PoseyCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA. jjernig@iu.edu.ORCID http://orcid.org/0000-0003-0771-384X
Kelly B MeneesCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0003-4282-8546
Malú Gámez TanseyCenter for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL, USA. mgtansey@iu.edu.ORCID http://orcid.org/0000-0002-1719-4708

Funding

Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
National Institute of Health and the National Institute of Neurological Disorders and Stroke RF1NS28800NINDS NIH HHS T32 NS082168NINDS T32 Pre-Doctoral Training Program in Movement Disorders and Neurorestoration 5T32NS082168-09The Michael J. Fox Foundation for Parkinson's Research (MJFF) and the Aligning Science Across Parkinson's (ASAP) initiative ASAP-020527
6 · The paper itself

Abstract

The inflammatory response mounted by the immune system is a protective process necessary for survival following exposure to insults. However, it must be tightly regulated to maximize efficient elimination of pathogens and to minimize collateral damage to the host. Failure to maintain balance and resolve an inflammatory response can result in chronic systemic inflammation (CSI). CSI has been identified as a key factor in the pathogenesis of many diseases including neurodegenerative diseases (NDs). This review covers the growing relationship between CSI and NDs with a particular emphasis on Parkinson's disease (PD). Furthermore, we discuss the role of an important negative regulator of inflammatory responses: Regulator of G-protein Signaling-10 (RGS10), within the context of CSI and PD.

Indexed as

InflammationParkinson DiseaseRGS ProteinsAnimalsHumansSignal TransductionRGS ProteinsChronic Systemic InflammationImmune DysregulationNeurodegenerative DiseasesNeuroinflammationParkinson’s DiseaseRegulator of G Protein Signaling 10 (RGS10)

Identifiers

PMID42174683
PMCPMC13374318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.