Evidence map›Paper›PMID 42174669›Full record

ArticleWorld journal of surgical oncology2026

Prognostic value of lymphovascular invasion and CEA for cancer-specific survival in octogenarian colorectal cancer patients.

Xiuping Weng, Yangyang Zhou, Yunzhu Zhang, Xiexi Fang, Rongbin Xu, Yiqiang Wang, Qi Qiu, Xiaoyuan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiuping WengGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital（Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yangyang ZhouGeneral Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital（Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yunzhu ZhangDepartment of Nursing, Linyi Central Hospital, Linyi, China.
Xiexi FangNeurosurgery Department, Ningbo No.2 Hospital, Ningbo, 315099, China.
Rongbin XuNursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yiqiang WangHangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang Province, China.
Qi QiuDepartment of Critical Care Medicine, Taizhou Central Hospital (Taizhou University Hospital), No.999 Donghai Avenue, Jiaojiang District, Taizhou, Zhejiang Province, 318001, China.
Xiaoyuan ChenCenter for Rehabilitation Medicine, Department of Rehabilitation, Comprehensive Rehabilitation Ward, Zhejiang Provincial People's Hospital（Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. chenxiaoyuan016@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the prognostic value of lymphovascular invasion (LVI) and preoperative carcinoembryonic antigen (CEA) level for cancer-specific survival (CSS) in octogenarian (≥ 80 years) colorectal cancer (CRC) patients, and to explore the modifying effects of tumor laterality and histological subtype on this prognostic value.

methodsThis retrospective cohort study enrolled 214 octogenarian CRC patients and 214 age-matched younger patients (50-79 years) as controls. The associations between LVI/CEA status and clinicopathological characteristics were analyzed. Kaplan-Meier curves and Cox proportional hazards models were used to evaluate prognostic impacts, with subgroup analyses by tumor laterality and histological subtype.

resultsOctogenarian patients had higher rates of LVI positivity (38.3% vs. 29.9%, P = 0.042) and elevated CEA (41.1% vs. 32.7%, P = 0.038) than younger patients, with a lower 5-year CSS rate (52.3% vs. 68.7%, P < 0.001). LVI positivity (HR = 2.14, 95% CI = 1.57-2.91, P < 0.001) and elevated CEA (HR = 1.87, 95% CI = 1.35-2.59, P < 0.001) were independent prognostic factors for worse CSS in octogenarians, with more pronounced adverse effects in right-sided colon cancer and adenocarcinoma subtypes.

conclusionLVI positivity and elevated preoperative CEA levels are independent prognostic factors for poor CSS in octogenarian CRC patients. Their prognostic impact varies by tumor laterality and histological subtype, highlighting the need for personalized risk stratification in this population.

Indexed as

Carcinoembryonic AntigenColorectal NeoplasmsAgedAged, 80 and overBiomarkers, TumorFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesSurvival RateBiomarkers, TumorCarcinoembryonic AntigenCancer-specific survivalCarcinoembryonic antigenColorectal cancerLymphovascular invasionOctogenariansPrognostic factors

Identifiers

PMID42174669
PMCPMC13371524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.