Evidence map›Paper›PMID 42174628›Full record

ArticleJournal of neuroinflammation2026

Sleep deprivation induces anxiety-like behaviors through IL-6 driven astrocyte-GABAergic neuron crosstalk in the PAG-ACC circuit.

Xiao Xu, Ziang Wu, Wenxin Hang, Shaojia Mao, Jiahui Sun, Huanbin Xiong, Jinpiao Zhu, Daqing Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao Xu *Perioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Ziang Wu *Perioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Wenxin HangPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Shaojia MaoPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Jiahui SunPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Huanbin XiongPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China.
Jinpiao ZhuPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China. zhujinpiao@zju.edu.cn.
Daqing MaPerioperative and Systems Medicine Laboratory, Department of Rehabilitation, Department of Anesthesiology, Children's Hospital, National Clinical Research Center for Children and Adolescents' Health and Diseases, Zhejiang University School of Medicine, Hangzhou, 310015, China. d.ma@imperial.ac.uk.

Funding

Children's Hospital of Zhejiang University School of Medicine Pre-Research Fund CHZJU2023YY006Key Project of Medical and Health Science and Technology Plan of Zhejiang Province WKJ-ZJ-2536National Natural Science Foundation of China 82401498"Pioneer" and "Leading Goose" R&D Program of Zhejiang 2025C02082Special Fund for the Incubation of Young Clinical Scientist, the Children's Hospital of Zhejiang University School of Medicine CHZJU2024YS001
6 · The paper itself

Abstract

Sleep deprivation (SD) is associated with anxiety-like behaviors, yet the underlying molecular and neural circuit mechanisms remain unclear. Using a 24-hour SD paradigm in mice, we found that SD induced anxiety-like behaviors and increased interleukin-6 (IL-6) in blood and the periaqueductal gray (PAG), and PAG-targeted administration of IL-6 receptor antagonist rescued the anxiety-like behaviors. This increased IL-6 activated PAG astrocytes, as evidenced by morphological remodeling, increased calcium activity, and enhanced glutamate release. Astrocytic activation upregulated several genes associated with endoplasmic reticulum (ER) protein synthesis and processing, including neuronal mesencephalic astrocyte-derived neurotrophic factor (Manf). Knockdown of Manf in PAG neurons upregulated the GABA

Indexed as

AnxietyAstrocytesGABAergic NeuronsInterleukin-6Periaqueductal GraySleep DeprivationAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysInterleukin-6AnxietyIL-6Mesencephalic astrocyte-derived neurotrophic factorPeriaqueductal grayPro-inflammatory cytokineSleep deprivation

Identifiers

PMID42174628
PMCPMC13374079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.