ReviewRespiratory research2026
Recent advances in pulmonary fibrosis: from lung surfactant to the immune connection.
Review in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary fibrosis (PF) encompasses a heterogeneous group of progressive interstitial lung diseases characterized by aberrant wound healing, extracellular matrix accumulation, and irreversible architectural remodeling of the lung. This review provides a comprehensive overview of the clinical spectrum, epidemiology, and genetic predisposition underlying PF, followed by an in-depth analysis of key molecular and cellular mechanisms driving fibrogenesis, including epithelial injury, dysregulated repair, profibrotic signaling pathways, and immune-mediated processes. Particular emphasis is placed on the role of lung surfactant dysfunction in fibrosis development, highlighting alterations in surfactant composition, metabolism, and associated genetic variants that contribute to epithelial stress and disease progression. The review also evaluates established and emerging circulating biomarkers, including serum proteins linked to epithelial damage, extracellular matrix remodeling, and immune activation, with attention to their diagnostic and prognostic utility. Finally, current and evolving therapeutic strategies are discussed in the context of progressive fibrosing phenotypes. Despite significant advances in understanding PF pathobiology, substantial gaps remain in early detection, disease stratification, and targeted treatment, underscoring the urgent need for improved translational approaches and precision medicine strategies.
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