Evidence map›Paper›PMID 42174434›Full record

SynthesisBMC gastroenterology2026

Comparison of early and late drainage interventions in necrotizing pancreatitis: a systematic review and meta-analysis.

Gaofeng Zhang, Bing Zhao, Tengang Deng, Xiaofei He, Yongpin Chen, Changtao Zhong, Jie Chen

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaofeng ZhangDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Bing ZhaoDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Tengang DengDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Xiaofei HeDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Yongpin ChenDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Changtao ZhongDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China.
Jie ChenDepartment of Center for Hepatobiliary-Pancreatic-Splenic Disease, Zigong Fourth People's Hospital, No. 2 Tanmulin Street, Zigong, Ziliujing District, 643000, China. chenjiezgsdsrmyy@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was designed to evaluate differences in mortality, complication rates, and length of hospital stay between early (≤ 4 weeks) and delayed (> 4 weeks) minimally invasive drainage in patients with necrotizing pancreatitis (NP) through the synthesis of existing evidence.

methodsDatabases including PubMed, Embase, and the Cochrane Library were searched up to November 1, 2025. Eligible randomized controlled trials (RCTs) and cohort studies were included. Literature screening and data extraction were conducted in accordance with the PRISMA guidelines, and a random-effects model was employed for meta-analysis.

resultsA total of 11 studies involving 1,697 patients were included. Meta-analysis results demonstrated that the mortality rate in the early drainage intervention group was significantly higher than that in the delayed drainage intervention group (RR = 1.38; 95%CI 1.05-1.81; P = 0.02), though the stability of this finding was poor. The proportion of patients requiring subsequent further debridement was significantly higher in the early drainage intervention group compared with the delayed drainage intervention group (RR = 2.05; 95%CI 1.26-3.31; P = 0.004). No significant differences were detected between the two groups in terms of length of hospital stay (P = 0.17), length of intensive care unit (ICU) stay (P = 0.25), or the incidence of complications (P > 0.05).

conclusionThis meta-analysis supports prioritizing delayed drainage in the treatment of NP, as it reduces the need for subsequent invasive debridement procedures; however, early drainage may still hold significant value patients with infection or organ failure.

Indexed as

DrainagePancreatitis, Acute NecrotizingDebridementHumansLength of StayTime FactorsEarly drainageLate drainageMeta-analysisNecrotizing pancreatitis

Identifiers

PMID42174434
PMCPMC13390132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.