Evidence map›Paper›PMID 42174420›Full record

ArticleBMC microbiology2026

Hyperinvasive and quinolone-resistant meningococci cc4821 achieved immune evasion through capsule switching.

Jiebin Huang, Panpan Lv, Yue Jiang, Youxing Shao, Mei Zeng, Qinglan Guo, Mingliang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiebin Huang *Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
Panpan Lv *Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Yue JiangDepartment of Emergency & Research and Translational Laboratory of Acute Injury and Secondary Infection, Minhang Hospital, Fudan University, Shanghai, 201199, China.
Youxing ShaoInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Mei ZengDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China. zengmei@fudan.edu.cn.
Qinglan GuoInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China. qinglanguo@fudan.edu.cn.
Mingliang ChenDepartment of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, 201199, China. cmlbright@126.com.

Funding

National Natural Science Foundation of China 81872909 and 82373918National Natural Science Foundation of China 82272381 and 82472322Wellcome Trust
6 · The paper itself

Abstract

backgroundNeisseria meningitidis stands as one of the predominant etiological agents of bacterial meningitis worldwide. Sequence type (ST) 4821 clonal complex (cc4821), notably linked to the hyperinvasive and quinolone-resistant clone China

resultsPhylogenetic analysis of the cps loci revealed that recombination events probably occurred in region A. Among MenB China

conclusionsThe potential capsule switch from MenC→MenB in China

Indexed as

Bacterial CapsulesDrug Resistance, BacterialImmune EvasionNeisseria meningitidisQuinolonesAnti-Bacterial AgentsChinaHumansMultigene FamilyPhylogenyRecombination, GeneticAnti-Bacterial AgentsQuinolonesCapsular polysaccharidesCapsule switchingImmune evasionNatural transformationNeisseria meningitidisSequence type 4821

Identifiers

PMID42174420
PMCPMC13378237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.