ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Normative cognitive data and psychometric validation of the 10/66 harmonized assessment protocol in Latin American.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThis study examined the latent cognitive structure of the 10/66 Dementia Research Group protocol and assessed its psychometric properties in culturally diverse older adults in Latin America and the Caribbean.
methodsData from 10,838 adults aged 65+ across five countries were analyzed. Confirmatory factor analyses tested unidimensional and multidimensional models representing major cognitive domains. Model fit, reliability, and a hierarchical second-order structure were examined. Measurement invariance was assessed across normative and non-normative subsamples and gender.
resultsA multidimensional structure emerged, comprising memory, orientation, executive functioning, semantic/language, and visuospatial domains, along with a higher-order global cognition factor. Most domains demonstrated adequate fit and acceptable reliability. The second-order model provided the best overall fit. Invariance was supported across all groups tested. DISCUSSION: This study provides the first empirical validation of the 10/66 protocol's latent structure, enabling the derivation of standardized cognitive scores and strengthening its utility for harmonized dementia research in diverse cultural settings.
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