Evidence map›Paper›PMID 42174393›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Numeracy, literacy, and formal education as mechanisms of inequities in late-life cognitive performance between Indigenous-speaking and non-Indigenous-speaking older Mexican adults.

Sirena Gutierrez, Zachary J Kunicki, Iris Strangmann, Alexa S Gonzalez, Gelan Ying, Sneha Sarah Mani, Jacqueline M Torres, Jennifer Weuve, Antonio Terracciano, Jet M J Vonk and 2 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sirena GutierrezDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.ORCID https://orcid.org/0000-0001-9201-698X
Zachary J KunickiDepartment of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
Iris StrangmannDepartment of Neurology, Columbia University Medical Center, New York City, New York, USA.
Alexa S GonzalezDepartment of Psychology, University of Houston, Houston, Texas, USA.
Gelan YingDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Sneha Sarah ManiDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
Jacqueline M TorresDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Jennifer WeuveDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Antonio TerraccianoDepartment of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida, USA.
Jet M J VonkEdward and Pearl Fein Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA.
Emily M BriceñoDepartment of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Miguel Arce RenteríaDepartment of Neurology, Columbia University Medical Center, New York City, New York, USA.

Funding

The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
Translational Epidemiology - Training for Research on Aging and Chronic diseaseT32AG049663 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Rose Mayeda, Mark J Pletcher · 2016 to 2026
$5.8M
Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias: Cross-national longitudinal prognosis and risk factorsRF1AG088009 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARCE, MIGUEL, BRICENO, EMILY MARIE · 2024 to 2024
$2.3M
MHAS Cognitive Aging Ancillary Study Administrative SupplementR01AG051158 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WONG, REBECA · 2015 to 2017
$1.1M
Factors of Resilience to Alzheimers Disease and Related Dementias among Latinx: The Role of BilingualismR00AG066932 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARCE, MIGUEL · 2023 to 2025
$938k
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG085953 · NIA · JOHNS HOPKINS UNIVERSITY · PI Alden L. Gross · 2024 to 2026
$150k
National Institutes of Health/National Institute on Aging R01AG018016National Institutes of Health/National Institute on Aging R01AG051158NIA NIH HHS R00 AG066932NIA NIH HHS R01 AG018016NIA NIH HHS R01 AG051158NIA NIH HHS R13 AG085953NIA NIH HHS RF1 AG088009NIA NIH HHS T32 AG049663NIH/NIA R00AG066932NIH/NIA R13AG085953NIH/NIA RF1AG088009NIH/NIA T32AG049663
6 · The paper itself

Abstract

introductionIndigenous adults face educational inequities, but it is unclear how education, literacy, and numeracy contribute to disparities in late-life cognition.

methodsThis study included 1958 adults ages 55+ (mean 68.1 [8.9 SD] years) from the Mexican Health and Aging Study (MHAS) Ancillary Study on Cognitive Aging (Mex-Cog; 2016). Linear regression models estimated associations between speaking an Indigenous language (vs. not) and cognitive factor scores, adjusting for sociodemographic covariates. Mediation analyses decomposed associations into direct and indirect effects via education, literacy, and numeracy.

resultsEleven percent of participants spoke an Indigenous language, which was associated with lower memory (β [95% confidence interval [CI] = -0.31 [-0.40, -0.21]), language (-0.65 [-0.75, -0.55]), executive function (-0.60 [-0.73, -0.47]), and orientation (-0.31 [-0.44, -0.18]) scores. Education explained 31%-61% of the association, literacy 11%-26%, and numeracy 2%-9%. DISUSSION: High-quality education may help reduce cognitive disparities in Mexico. Future research should address data limitations by collecting measures of Indigeneity beyond language use (e.g., self-identification, colorism).

Indexed as

CognitionEducational StatusLanguageLiteracyAgedAged, 80 and overAgingExecutive FunctionFemaleHumansMaleMexicoMiddle AgedNeuropsychological TestsSocioeconomic Disparities in HealthagingcognitionepidemiologyilliteracyindigeneityinequalitylanguagemediationMexicoschooling

Identifiers

PMID42174393
PMCPMC13240023

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.