Evidence map›Paper›PMID 42174391›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Integrating noise as a risk factor in studies of Alzheimer's disease and dementia: Guidance for epidemiologic research.

Matthew Bozigar, Jennifer Weuve, Sierra N Clark, Stephanie T Grady, Manuella Lech Cantuaria, Yutong Samuel Cai, Charlotte Roscoe, Martin Röösli, Junenette L Peters, Edmund Seto and 11 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Matthew BozigarSchool of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon, USA.ORCID https://orcid.org/0000-0003-0429-0247
Jennifer WeuveDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Sierra N ClarkDepartment of Population Health & Policy, School of Health and Medical Sciences, City St George's, University of London, London, UK.
Stephanie T GradyDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Manuella Lech CantuariaWork, Environment and Cancer, Danish Cancer Institute, Copenhagen, Denmark.
Yutong Samuel CaiCentre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.
Charlotte RoscoeEnvironmental Systems and Human Health, Oregon Health & Science University-Portland State University (OHSU-PSU) School of Public Health, Portland, Oregon, USA.
Martin RöösliSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Junenette L PetersDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Edmund SetoDepartment of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA.
Danielle VienneauJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Mette SørensenWork, Environment and Cancer, Danish Cancer Institute, Copenhagen, Denmark.
Richard L NeitzelSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Aaron L HastingsVolpe National Transportation Systems Center, U.S. Department of Transportation, Cambridge, Massachusetts, USA.
Thomas J LubenSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Zorana Jovanovic AndersenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Charlotte ClarkDepartment of Population Health & Policy, School of Health and Medical Sciences, City St George's, University of London, London, UK.
Anna L HansellCentre for Environmental Health and Sustainability, University of Leicester, Leicester, UK.
Perry HystadSchool of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon, USA.
Michael BrauerSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
Sara D AdarSchool of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Gateway Exposome Coordinating Center (GECC) For AD/ADRD ResearchU24AG088894 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, David Michael Keith Knapp · 2024 to 2026
$14.8M
NIA NIH HHS U24 AG088894NIA NIH HHS U24AG088894NIOSH CDC HHS T42 OH008455
6 · The paper itself

Abstract

Noise exposure is increasingly recognized as a modifiable environmental risk factor for Alzheimer's disease and related dementias (ADRD), yet its integration into epidemiologic research remains limited. We reviewed international noise mapping resources, exposure metrics, and analytic approaches relevant to ADRD studies. Mechanistic pathways and methodological challenges were synthesized from recent studies via expert knowledge. We present a stepwise framework for integrating noise into ADRD research, detailing metric selection, spatiotemporal assignment, and analytic guardrails. Our review recommends the application of 24-hour average, nighttime, and event-based metrics, and stresses that health effects may occur at low noise levels. We further underscore the importance of accounting for indoor, occupational, and life course exposures. Rigorous noise exposure assessment and transparent reporting will improve comparability and causal inference in ADRD studies. Future research should harmonize exposure metrics, integrate co-exposures (e.g., air pollution), and clarify etiologically relevant windows to strengthen prevention strategies.

Indexed as

Alzheimer DiseaseDementiaEnvironmental ExposureNoiseEpidemiologic StudiesHumansRisk Factorscognition disordersenvironmental exposureenvironment designpublic healthrisk assessmentspatial analysis

Identifiers

PMID42174391
PMCPMC13239928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.