Evidence map›Paper›PMID 42174381›Full record

ArticleChemMedChem2026

Redox Disruption Induced by Saquayamycin B1 Promotes Cytotoxicity in Resistant Melanoma Cells.

Geovana Guedes Silvestre, Thalisson Amorim de Souza, Alan Ferreira Alves, Valeria Dutan-Patiño, Jean-Michel Huvelin, Mathilde Gourdel, Mikael Croyal, Samuel Cibulski, Demetrius Antonio Machado de Araújo, Marcus Tullius Scotti and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Geovana Guedes SilvestrePostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.
Thalisson Amorim de SouzaPostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.
Alan Ferreira AlvesPostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.
Valeria Dutan-PatiñoUR2160 ISOMER, Nantes University, Nantes, France.
Jean-Michel HuvelinUR2160 ISOMER, Nantes University, Nantes, France.
Mathilde GourdelCHU Nantes, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes University, Nantes, France.
Mikael CroyalCHU Nantes, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes University, Nantes, France.
Samuel CibulskiFACISA, Federal University of Rio Grande do Norte, Santa Cruz, Brazil.ORCID 0000-0003-0503-8692
Demetrius Antonio Machado de AraújoCBIOTEC, Biotechnology Center, Federal University of Paraíba, João Pessoa, Brazil.
Marcus Tullius ScottiPostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0003-4863-8057
Josean Fechine TavaresPostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.
Angela TesseUMR Inserm 1235 TENS, Nantes University, Nantes, France.ORCID 0000-0002-2153-4357
El-Hassan NazihUR2160 ISOMER, Nantes University, Nantes, France.
Marianna Vieira SobralPostgraduate Program of Bioactives Natural and Synthetics Products, PgPNSB, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-7740-034X

Funding

Foundation of Research Support of Paraíba - FAPESQ-PB 11/2024
6 · The paper itself

Abstract

Melanoma is an aggressive skin cancer characterized by rapid progression and frequent chemoresistance, which limits the success of current therapies. Saquayamycin B1 (SQ-B1), an angucycline isolated from Streptomyces sp. I072, was investigated for its antimelanoma activity with emphasis on redox disruption. The compound was purified using M9 fermentation followed by semipreparative liquid chromatography, and its structure was confirmed through 1D/2D nuclear magnetic resonance (NMR) and mass spectrometry. Cytotoxicity assays (MTT, 72 h) in SK-MEL-5, -113, -117, and -134 cells revealed IC

Indexed as

AnthraquinonesAntineoplastic AgentsDrug Resistance, NeoplasmMelanomaAngucyclines and AngucyclinonesCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureOxidation-ReductionReactive Oxygen SpeciesStreptomycesAngucyclines and AngucyclinonesAnthraquinonesAntineoplastic AgentsReactive Oxygen Speciesangucyclineselectronic paramagnetic resonance (EPR)glutathione S‐transferase pi 1‐1 (GSTP1‐1)oxidative stressStreptomyces

Identifiers

PMID42174381
PMCPMC13206169

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.