Evidence map›Paper›PMID 42174353›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

The genes zntA and zntR encoding a P-type ATPase and its activator confer zinc and cadmium resistance in Chromobacterium violaceum.

Carolina Panosso Schuindt, Bianca Bontempi Batista, Lucas Cesetti, Sergio Pereira Lima Neto, Thierry Soldati, José Freire da Silva Neto

Abstract read
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In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina Panosso SchuindtDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Bianca Bontempi BatistaDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Lucas CesettiDepartment of Biochemistry, University of Geneva, Sciences II, Geneva-4, CH-1211, Geneva, Switzerland.
Sergio Pereira Lima NetoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Thierry SoldatiDepartment of Biochemistry, University of Geneva, Sciences II, Geneva-4, CH-1211, Geneva, Switzerland.
José Freire da Silva NetoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil. jfsneto@usp.br.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06894-0 and 2021/10577-0Swiss National Science Foundation 310030E_213739
6 · The paper itself

Abstract

The transition metal zinc is an essential trace element for life but becomes toxic at high concentrations. In the opportunistic pathogen Chromobacterium violaceum, zinc acquisition is crucial for virulence, yet how this bacterium copes with zinc toxicity remains unknown. In this work, we demonstrate that C. violaceum senses and responds to excess zinc by activating the zntA gene, which encodes a P

Indexed as

Adenosine TriphosphatasesBacterial ProteinsCadmiumChromobacteriumP-type ATPasesZincDrug Resistance, BacterialAdenosine TriphosphatasesBacterial ProteinsCadmiumP-type ATPasesZincCadmium resistanceChromobacterium violaceumEfflux pumpMetal toxicityTranscription factorZinc resistance

Identifiers

PMID42174353
PMCPMC13518485

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.