Evidence map›Paper›PMID 42174228›Full record

ReviewNature chemical biology2026

Large glycomics datasets as a tool to understand the function of glycans.

Maja Pučić-Baković, Tamara Štambuk, John P A Ioannidis, Vlatka Zoldoš, Wei Wang, Gordan Lauc

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maja Pučić-BakovićGenos, Glycoscience Research Laboratory, Zagreb, Croatia.ORCID http://orcid.org/0000-0003-0866-623X
Tamara ŠtambukGenos, Glycoscience Research Laboratory, Zagreb, Croatia.
John P A IoannidisMeta-Research Innovation Center at Stanford (METRICS), Stanford University School of Medicine, Stanford, CA, USA.
Vlatka ZoldošGenos, Glycoscience Research Laboratory, Zagreb, Croatia.
Wei Wang *Institute for Glycome Study and First Affiliated Hospital of Shantou University Medical College, Shantou, China.ORCID http://orcid.org/0000-0002-1430-1360
Gordan Lauc *Genos, Glycoscience Research Laboratory, Zagreb, Croatia. glauc@pharma.hr.ORCID http://orcid.org/0000-0003-1840-9560

Funding

EC | European Regional Development Fund (Europski Fond za Regionalni Razvoj) KK.01.1.1.04.0085European Commission (EC) 101071386European Commission (EC) 101080784European Commission (EC) 101094099European Commission (EC) 101214245Hrvatska Zaklada za Znanost (Croatian Science Foundation) 2022-10-1358
6 · The paper itself

Abstract

Historically, glycomics has lagged behind other omics fields, owing to analytical challenges. However, recent technological advances are rapidly transforming the field, enabling a growing number of large-scale studies to harness the wealth of information encoded by glycans. In this Review, we provide an overview of the current state of large-scale glycomics and its role in understanding the functional importance of glycans. We discuss the main challenges in high-throughput glycoanalytical methods and highlight recent progress, with a particular emphasis on standardization and reproducibility. Special attention is given to the necessity of large, well-designed and ideally longitudinal and multicohort studies that use rigorous statistical approaches to uncover robust biological associations. Finally, we conclude with selected applications and perspectives, emphasizing the potential of large-scale glycomics to drive biomarker discovery and enhance the understanding of glycan-mediated biology.

Indexed as

GlycomicsPolysaccharidesAnimalsBiomarkersHumansBiomarkersPolysaccharides

Identifiers

PMID42174228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.