Evidence map›Paper›PMID 42174208›Full record

ReviewNature protocols2026

Chiral multimodal nanoprobes for sensing of biomarkers.

Changlong Hao, Panpan Chen, Aihua Qu, Maozhong Sun, Liguang Xu, Chuanlai Xu, Hua Kuang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changlong HaoInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Panpan ChenInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Aihua QuInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China. quaihua1992@163.com.
Maozhong SunInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Liguang XuInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Chuanlai XuInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China. xcl@jiangnan.edu.cn.ORCID http://orcid.org/0000-0002-5639-7102
Hua KuangInternational Joint Research Laboratory for Biointerface and Biodetection, State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China. kuangh@jiangnan.edu.cn.ORCID http://orcid.org/0000-0002-2724-8722

Funding

China National Funds for Distinguished Young Scientists 32471430National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 23447631National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32471430National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 92156003
6 · The paper itself

Abstract

Biomarker detection for early disease diagnosis demands materials with high sensitivity and anti-interference capability. However, conventional single-signal nanosensors often fail in complex biological matrices due to autofluorescence and matrix interference. Here, to address these challenges, we report the synthesis of chiral multimodal nanoprobes that integrate circular dichroism, fluorescence and magnetic resonance signals. These probes, constructed using either 'intrinsic chiral nanomaterials' or 'hybrid chiral assemblies', leverage synergistic interactions between chiral frameworks and target analytes to enable orthogonal signal cross-validation. The operation time for their synthesis is usually less than 6 h, includes rapid screening (~1 h) of sensitivity and selectivity through optimization of spectral parameters. This strategy accelerates the development of advanced sensing materials, offering a robust platform for biomarker detection in biomedical applications. The protocol requires familiarity with nanomaterial synthesis, surface functionalization and spectroscopic characterization.

Indexed as

BiomarkersBiosensing TechniquesNanostructuresCircular DichroismMagnetic Resonance SpectroscopyBiomarkers

Identifiers

PMID42174208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.