Evidence map›Paper›PMID 42174151›Full record

ArticleLab animal2026

Twist1 overexpression models an aggressive subtype of pancreatic ductal adenocarcinoma in vivo.

Muhammad Ajmal Khan, Jinhee Chang, Yang Song, Amol C Shetty, Triet Nguyen, Danielle N Waters, Dipanwita Dutta Chowdhury, Elan Simms, Aaron Chan, Hwai Wei Tseng and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Muhammad Ajmal Khan *Department of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3817-3631
Jinhee Chang *Department of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3603-403X
Yang SongDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Amol C ShettyDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Triet NguyenDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Danielle N WatersDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Dipanwita Dutta ChowdhuryDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Elan SimmsDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Aaron ChanDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Hwai Wei TsengDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Christine LamDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Priyanshi PatelDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Lucas T TranDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Jiayu ChenDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Jarey H WangDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Katriana NugentDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Matthew BallewDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Ghali Lemtiri-ChliehDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Francesca Anna CarrieriDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA.
Reem MalekDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Hailun WangDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Noelle R Jurcak ThielmanDepartment of Immunology and Microbiology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.ORCID http://orcid.org/0000-0002-2260-8055
Keyu LiDepartment of Pancreatic Surgery West China Hospital, SCU, Chengdu, China.
Ryan J ParkDepartment of GU Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0003-4725-2937
William L HwangCenter for Systems Biology, Center for Cancer Research, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Lei ZhengDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4163-2541
Kathleen GabrielsonDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Phuoc T TranDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA. pttran6@mdanderson.org.ORCID http://orcid.org/0000-0002-0147-0376
Audrey LafargueDepartment of Radiation Oncology, Division of Translational Radiation Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, MD, USA. alafargue@mdanderson.org.ORCID http://orcid.org/0000-0001-9551-2815

Funding

Resource Sharing CoreU54CA273956 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Luigi Marchionni · 2022 to 2026
$8.9M
Tumor-barcoding coupled with high-throughput sequencing of a novel chemoradiation resistant SCLC mouse modelU01CA231776 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANN, CHRISTINE L., MARCHIONNI, LUIGI · 2018 to 2022
$3.9M
Integrating bioinformatics into multiscale models for hepatocellular carcinomaU01CA212007 · NCI · JOHNS HOPKINS UNIVERSITY · PI EWALD, ANDREW JOSEF, FERTIG, ELANA · 2018 to 2022
$3.2M
Tumor-barcoding coupled with high-throughput sequencing for quantitative radiogenomics of the abscopal response in NSCLCR01CA271540 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Phuoc T. Tran · 2023 to 2026
$2.3M
Elucidating cancer-intrinsic mechanisms of perineural invasion in pancreatic cancerK08CA270417 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI William L Hwang · 2022 to 2026
$1.6M
A pre-clinical x-ray/optical tomography-guided radiation research platform for pancreatic cancerR21CA223403 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TRAN, PHUOC T., WANG, KEN KANG-HSIN · 2018 to 2019
$386k
NCI NIH HHS K08 CA270417NCI NIH HHS R01 CA271540NCI NIH HHS R21 CA223403NCI NIH HHS U01 CA212007NCI NIH HHS U01 CA231776NCI NIH HHS U54 CA273956
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with poor survival outcomes. Genomic analyses have identified distinct molecular subtypes in human PDAC with the quasimesenchymal/squamous/basal-like (QSB) subtype having the worst prognosis. However, no in vivo models exist for QSB subtypes. The epithelial-mesenchymal transition (EMT) transcription factor TWIST1 is upregulated in QSB PDAC. Here we hypothesized that TWIST1-dependent plasticity is a key regulator of QSB PDAC subtype development. Non-negative matrix factorization (NMF) of human PDAC subtypes identified three NMF clusters. NMF1 was dominated by QSB subtypes, had the worst survival and exhibited high TWIST1 expression. We generated a novel tetracycline-inducible autochthonous pancreas-specific Kras

Indexed as

Carcinoma, Pancreatic DuctalNuclear ProteinsPancreatic NeoplasmsTwist-Related Protein 1AnimalsDisease Models, AnimalEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMiceMice, TransgenicNuclear ProteinsTwist1 protein, mouseTwist-Related Protein 1

Identifiers

PMID42174151
PMCPMC13487728

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.