Evidence map›Paper›PMID 42174134›Full record

ArticleNature cell biology2026

Stress granules restrain ferroptosis by sequestering ferritin.

Zehe Ge, Zihan Wang, Erjie Zhao, Yizhuo Guo, Longxiu Zhang, Fuwei Tian, Mengdie Li, Yunfei Ma, Fangshu Ding, Liuguijie He and 21 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Zehe Ge *Jiangsu Key Laboratory of Innovative Cancer Diagnosis and Therapeutics, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-7063-244X
Zihan Wang *Department of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Erjie Zhao *Department of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yizhuo Guo *Digital Intelligence Neural Research Laboratory, Department of Neurosurgery, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, China.
Longxiu ZhangDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Fuwei TianDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Mengdie LiDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Yunfei MaDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-4448-9472
Fangshu DingDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Liuguijie HeDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Shuhong SunDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Minfeng TongDepartment of Neurosurgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Wenxia XuCentral Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.
Xiefeng WangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Junxia ZhangDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0003-1622-8045
Lingxiang WuDepartment of Bioinformatics, Nanjing Medical University, Nanjing, China.
Yudan ZhangDepartment of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Lili NiuDepartment of Medical Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Qianghu WangDepartment of Bioinformatics, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-3488-1059
Rong YinJiangsu Key Laboratory of Innovative Cancer Diagnosis and Therapeutics, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-9744-4251
Xiao LiDepartment of Urologic Surgery, Jiangsu Cancer Hospital & Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Yongping YouDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jeremy N RichUniversity of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7845-5302
Xiuxing WangDepartment of Cell Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-5993-9368
Bing YaoNational Experimental Teaching Center of Basic Medical Science, School of Basic Medical Sciences, Department of General Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-6657-2760
Zhumei ShiDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. shizhumei@njmu.edu.cn.ORCID http://orcid.org/0000-0003-1664-7135
Zhou YangDepartment of Medical Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. zhouyang17@tongji.edu.cn.ORCID http://orcid.org/0000-0003-3072-271X
Xin GeDepartment of Nutrition and Food Hygiene, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. xinge@njmu.edu.cn.ORCID http://orcid.org/0000-0003-4825-6534
Fang LiuDigital Intelligence Neural Research Laboratory, Department of Neurosurgery, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. czdoctorliu@hotmail.com.ORCID http://orcid.org/0000-0003-2881-8114
Bo ChuDepartment of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. chubo123@sdu.edu.cn.ORCID http://orcid.org/0000-0001-9754-2743
Xu QianJiangsu Key Laboratory of Innovative Cancer Diagnosis and Therapeutics, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. xqianmedres@njmu.edu.cn.ORCID http://orcid.org/0000-0003-1533-8568

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82372829National Natural Science Foundation of China (National Science Foundation of China) 82372990National Natural Science Foundation of China (National Science Foundation of China) 82373215National Natural Science Foundation of China (National Science Foundation of China) 82404253National Natural Science Foundation of China (National Science Foundation of China) 82472668
6 · The paper itself

Abstract

Glioblastoma stem cells (GSCs) are refractory to first-line treatment in the clinic, which includes irradiation (IR) and temozolomide (TMZ). Here we find that disrupting stress granules (SGs) sensitizes GSCs to IR/TMZ through ferroptosis. The profiling of SG proteins reveals the recruitment of iron-related proteins including ferritin. Mechanistically, G3BP1, an SG core protein, directly interacts with ferritin light chain in an IR/TMZ-induced G3BP1 methionine-333 oxidation-dependent manner. This interaction facilitates recruiting and sequestering ferritin into SGs, thereby restricting ferroptosis by limiting Fe

Indexed as

ApoferritinsBrain NeoplasmsFerritinsFerroptosisGlioblastomaNeoplastic Stem CellsStress GranulesAnimalsCell Line, TumorDNA HelicasesHumansIronMiceRNA HelicasesTemozolomideApoferritinsDNA HelicasesFerritinsIronRNA HelicasesTemozolomide

Identifiers

PMID42174134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.