ArticleScientific reports2026
Hypoxia, metastatic origin and HPV16 E6/E7 expression differentially shape the radiation response in head and neck squamous cell carcinoma cell lines.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hypoxia, a common feature of head and neck squamous cell carcinoma (HNSCC), significantly compromises radiotherapy efficacy by modulating DNA repair, cell‑cycle progression, and inflammatory signaling pathways. In addition, intrinsic tumor heterogeneity-including tumor origin and human papillomavirus (HPV) oncogene expression-further shapes therapeutic response. Despite these recognized factors, the integrated impact of oxygen tension, tumor origin, and viral oncogene expression on radiation response remains poorly defined. We examined the effects of hypoxia (1% O
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