ArticleThe EMBO journal2026
Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.
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In one paragraph
Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU.Nature metabolism · 2026Article
- Matrix and intermembrane space-specific mitochondrial stress response in Alzheimer's disease.NPJ dementia · 2026Article
- MICU proteins facilitate CaResearch square · 2025Article
- Mitochondrial connection to Alzheimer's disease and heart failure.Current opinion in physiology · 2025Article
- Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis.Biochimica et biophysica acta. Molecular basis of disease · 2024Review
- Review
- Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.iScience · 2023Article
- Post-translational modifications and protein quality control of mitochondrial channels and transporters.Frontiers in cell and developmental biology · 2023Review
Corrections and comments
- Update of
Authors and funding
14 authors.
Pooja JadiyaAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Elena BerezhnayaAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Devin W KolmetzkyAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dhanendra TomarAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Henry M CohenAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2172-2008
Shatakshi ShuklaDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Manfred ThomasAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Salman KhalediAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Joanne F GarbinciusAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4334-6445
Liam KennedyAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0003-2372-3447
Oniel SalikAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Darpan RaghavDepartment of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Alycia N HildebrandAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
John W ElrodAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. elrod@temple.edu.ORCID http://orcid.org/0000-0003-3925-2224
Funding
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Douglas Tilley · 2017 to 2026
$21.0MTargeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MNovel Molecular Mechanisms of Programmed NecrosisR01HL136954 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2017 to 2020
$1.6MMitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5MImpact of mitochondrial structure on cellular homeostasis and hepatic injuryR00DK120876 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOMAR, DHANENDRA · 2022 to 2024
$986kMitochondrial calcium uptake in Alzheimer's diseaseK99AG065445 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI JADIYA, POOJA · 2020 to 2021
$208kImpact of mitochondrial structure on cellular homeostasis and hepatic injuryK99DK120876 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI TOMAR, DHANENDRA · 2020 to 2021
$181kThe Role of MICU3 in Alzheimer's Disease PathogenesisF30AG082407 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI Henry Cohen · 2023 to 2026
$178kMolecular modulation of the mitochondrial Na+/Ca2+ exchanger as a novel therapeutic target for heart failure.F32HL151146 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GARBINCIUS, JOANNE FRANCES · 2020 to 2021
$134kAlzheimer's Association 24AARG-D-1191292Alzheimer's Association (AA) 24AARG-D-1191292American Heart Association (AHA) 20EIA35320226American Heart Association (AHA) 24IPA1273195American Heart Association-American Stroke Association 24IPA1273195HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 3R01HL123966-05S1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL151146HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL134608HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL147841HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL136954HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL142271HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K99DK120876HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS121379HHS | NIH | National Institute on Aging (NIA) F30AG082407HHS | NIH | National Institute on Aging (NIA) K99AG065445NIA NIH HHS K99 AG065445NIDDK NIH HHS K99 DK120876NIDDK NIH HHS R00 DK120876Pennsylvania Department of Health (DOH) 420792WFU | WFSM | Alzheimer's Disease Research Center, Wake Forest School of Medicine (ADRC) P30AG072947
Abstract
Loss of
Indexed as
Alzheimer DiseaseCalciumCalcium ChannelsMitochondriaNeuronsAnimalsDisease Models, AnimalDisease ProgressionHumansMiceMice, TransgenicMitochondrial ProteinsCalciumCalcium ChannelsMcu protein, mousemitochondrial calcium uniporterMitochondrial Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.