Evidence map›Paper›PMID 42174107›Full record

ArticleScientific reports2026

Association between mucus phenotypes, histopathological features, and ultra-high magnification endoscopic findings in ulcerative colitis.

Takeshi Hashimoto, Hiroki Kurumi, Shungo Kanetsuki, Tsutomu Kanda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kazuo Yashima, Tomohiko Sakabe, Yoshihisa Umekita, Hajime Isomoto

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takeshi HashimotoDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Hiroki KurumiDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan. kurumi_1022_1107@yahoo.co.jp.
Shungo KanetsukiDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Tsutomu KandaDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Yuichiro IkebuchiDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Koichiro KawaguchiDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Kazuo YashimaDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.
Tomohiko SakabeDepartment of Pathology, Faculty of Medicine, Tottori University, Tottori, Japan.
Yoshihisa UmekitaDepartment of Pathology, Faculty of Medicine, Tottori University, Tottori, Japan.
Hajime IsomotoDivision of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Tottori, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colonic mucosa. Changes in mucin phenotype may be associated with mucosal inflammation in UC. However, the relationship between clinicopathological features and mucus phenotypes in UC remains unclear. Therefore, we aimed to evaluate the association between mucus phenotypes and clinicopathological features in patients with UC using immunohistochemistry, as well as their association with ultra-high magnification endocytoscopy (EC) classification. A total of 51 lower gastrointestinal endocytoscopy procedures were performed for 39 patients with UC between 2018 and 2022. MUC2 expression was positive in all biopsy specimens, whereas MUC1, MUC6, and CD10 expression was negative. MUC5AC was expressed in 51.3% of cases. MUC5AC positivity was associated with duration of disease, classification by clinical course, Mayo score, Mayo endoscopic subscore (MES), Nancy histological index, C-reactive protein levels, erythrocyte sedimentation rate, and EC classification at the patient level. At the specimen level, significant differences were observed in the Nancy histological index, MES, and EC classification. In multivariate analysis, the Nancy histological index showed a significant correlation.MUC5AC is strongly correlated with histopathological severity and may also be associated with clinical and endoscopic severity. The clinical significance of MUC5AC positivity remains a topic for future investigation.

Indexed as

Colitis, UlcerativeIntestinal MucosaMucusAdultAgedFemaleHumansImmunohistochemistryMaleMiddle AgedMucin-1Mucin-2Mucin 5ACMucin-6NeprilysinPhenotypeMUC1 protein, humanMUC2 protein, humanMUC5AC protein, humanMUC6 protein, humanMucin-1Mucin-2Mucin 5ACMucin-6NeprilysinEndocytoscopyMUC5ACMucinMucus phenotypeUlcerative colitis

Identifiers

PMID42174107
PMCPMC13507151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.