Evidence map›Paper›PMID 42174105›Full record

Observational studyScientific reports2026

Choroidal structure as predictor of macular changes and visual outcomes after panretinal photocoagulation in eyes with very severe NPDR and early PDR without center-involving DME.

Esmaeil Asadi Khameneh, Mohammadreza Mehrabi Bahar, Nastaran Abbasian, Baharan Rahmani Chianeh, Alireza Khodabandeh, Elias Khalili Pour, Hamid Riazi-Esfahani

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Esmaeil Asadi KhamenehRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran.
Mohammadreza Mehrabi BaharRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran.
Nastaran AbbasianRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran.
Baharan Rahmani ChianehUrmia University of Medical Sciences, Urmia, Iran.
Alireza KhodabandehRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran.
Elias Khalili PourRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran. ekhalilipour@gmail.com.
Hamid Riazi-EsfahaniRetina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, 14176-13151, Tehran, Iran. hamidriazi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Panretinal photocoagulation (PRP) is widely used for advanced diabetic retinopathy, yet its effects on retinal and choroidal architecture remain incompletely characterized. This prospective observational study evaluated retinal and choroidal structural changes after PRP in 39 eyes of 21 patients with very severe non-proliferative diabetic retinopathy (NPDR) or early proliferative diabetic retinopathy (PDR) without center-involving diabetic macular edema (DME) using enhanced depth imaging optical coherence tomography (EDI-OCT) at baseline and at 1 and 3 months post-treatment. Quantitative parameters included foveal and whole macular thickness, subfoveal choroidal thickness (SFCT), and choroidal vascularity index (CVI), while intraretinal fluid (IRF) and hyperreflective foci (HF) were evaluated by masked graders. Foveal thickness increased significantly at 1 month (p = 0.017) and 3 months (p = 0.032), and whole macular thickness increased at 1 month (p < 0.001), with stable visual acuity. SFCT increase at 1 month was associated with retinal thickening (B = 0.154, p = 0.008). CVI elevation at 1 month correlated with visual improvement (B = - 0.015, p = 0.013), whereas CVI increase at 3 months was associated with visual decline (B = 0.019, p = 0.007). SFCT increase at 3 months was significantly associated with IRF formation (p = 0.016), indicating that EDI-OCT-derived choroidal metrics may serve as predictive biomarkers of post-PRP macular structural and functional responses.

Indexed as

ChoroidDiabetic RetinopathyLight CoagulationMacula LuteaMacular EdemaAgedFemaleHumansLaser CoagulationMaleMiddle AgedProspective StudiesRetinaTomography, Optical CoherenceTreatment OutcomeVisual AcuityChoroidal vascularity index(CVI)Diabetic retinopathyMacular thicknessPanretinal photocoagulationSubfoveal choroidal thickness (SFCT)

Identifiers

PMID42174105
PMCPMC13402825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.