ArticleScientific reports2026
Ferroptosis-related proteins orchestrate aortic dissection: unveiling novel molecular signatures and therapeutic avenues.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Targeting cGAS-STING and Ferroptosis in Aortic Disease: Another Aspirin Discovery.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
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8 authors.
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Abstract
AD (Aortic dissection) is a life-threatening cardiovascular emergency. Initially, through integrated bioinformatics analysis, we screened proteomic data from AD and control samples. By combining this with a ferroptosis-related database, 22 key ferroptosis-associated proteins were identified. Multidimensional analyses (including heatmaps and volcano plots) were used to visualize differences in protein abundance and pathway disruptions. Functional annotation via GO and KEGG enrichment analyses revealed that these proteins are involved in critical biological processes such as oxidative stress and inflammation. Validation through Western blot, immunohistochemistry, RT-qPCR, and single-cell RNA sequencing confirmed that these proteins (HO-1, SNCA) are significantly upregulated in AD and exhibit distinct cellular distribution patterns. Single-cell analysis further identified specific cell populations that drive ferroptosis-related events. These findings underscore the role of ferroptosis as a key molecular mechanism in the pathogenesis of AD. By integrating insights from proteomics with cellular-level distribution patterns, this study identified novel therapeutic targets, marking a significant breakthrough in the understanding and potential treatment of this devastating disease.
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