Evidence map›Paper›PMID 42174045›Full record

ArticleScientific reports2026

Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via G

Sihao Zou, Yi Wang, Jia Chen, Li Yan, Lijie Gao, Kexin Li, Xianying Wang, Congxin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sihao ZouDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Yi WangDepartment of Pharmacology, The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Medical University, No. 361 Zhongshan East Road, Chang'an District, Shijiazhuang, 050017, Hebei, China.
Jia ChenDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Li YanDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Lijie GaoDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Kexin LiDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Xianying WangDepartment of Pharmacy, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China.
Congxin LiDepartment of Pharmacy, Hebei Provincial Key Laboratory of Precision Anesthesiology and Organ Protection, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang, 050051, Hebei, China. congxinli@hebmu.edu.cn.

Funding

Natural Science Foundation of Hebei Province H2023206320Scientific Research Project of Hebei Medical University Third Hospital ydsypy202406Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine 2025337
6 · The paper itself

Abstract

In this study, age-related alterations in cardiac electrophysiology and the response to β

Indexed as

AgingArrhythmias, CardiacGTP-Binding Protein alpha Subunits, Gi-GoReceptors, Adrenergic, beta-2Signal TransductionAction PotentialsAdrenergic beta-2 Receptor AgonistsAlbuterolAnimalsGalactoseGuinea PigsHumansInduced Pluripotent Stem CellsMaleMyocytes, CardiacPhospholipase C gammaAdrenergic beta-2 Receptor AgonistsAlbuterolGalactoseGTP-Binding Protein alpha Subunits, Gi-GoPhospholipase C gammaReceptors, Adrenergic, beta-2AgingArrhythmiasHuman-induced pluripotent stem cell-derived cardiomyocytesSlow delayed rectifier potassium channelsβ2-adrenoceptor

Identifiers

PMID42174045
PMCPMC13408997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.