ArticleScientific reports2026
Association between body composition, knee synovial effusion, and serum glutamate in middle-aged women with knee osteoarthritis: a cross-sectional study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
This cross-sectional study investigated the association between knee synovial effusion, body composition, and serum glutamate levels in middle-aged women with knee osteoarthritis. Female participants (n = 241) from a health promotion project were classified into control (n = 165), early (n = 34), and definitive (n = 42) knee osteoarthritis groups. Synovial effusion was assessed based on the ultrasonographic effusion area, body composition via bioelectrical impedance, and serum glutamate from fasting blood samples. Muscle mass was higher in the definitive group than in the control (p = 0.009). Fat mass increased from normal to definitive, showing a significant difference between the control and definitive groups (p = 0.047). The effusion area correlated with muscle mass (r = -0.122, p < 0.05) and glutamate levels (r = 0.154, p < 0.001). Logistic regression identified fat mass as an associated factor of early (OR = 1.089, p = 0.004) and definitive (odds ratio = 1.063, p = 0.005) knee osteoarthritis, suggesting a potential association between adiposity and knee osteoarthritis. A weak correlation was observed between serum glutamate and synovial effusion. These findings underscore the importance of body composition optimization as a potential approach in the context of knee osteoarthritis management.
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