Evidence map›Paper›PMID 42173918›Full record

ArticleNPJ science of food2026

Nutritional methionine restriction modulates gut microbiota and propionate/GPR41 signaling to mitigate diabetic kidney disease.

Yuyu Zhang, Da Wang, Chuhan Wang, Yiju Li, Jingxi Pang, Xuebo Liu, Zhigang Liu, Tian Yuan

Abstract read
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In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuyu ZhangLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Da WangLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Chuhan WangLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Yiju LiAgriculture/Forestry Centre, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Jingxi PangLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Xuebo LiuLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China.
Zhigang LiuLaboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, China. zhigangliu@fudan.edu.cn.
Tian YuanNorthwest A&F University Shenzhen Research Institute, Shenzhen, China. tian.yuan@nwsuaf.edu.cn.

Funding

Basic Research Project of Shenzhen Natural Science Foundation JCYJ20220530161401004Basic Research Project of Shenzhen Natural Science Foundation JCYJ20230807111402005GuangDong Basic and Applied Basic Research Foundation 2021A1515110813Shaanxi Laboratory of Arid Area Agriculture 2024ZY-JCYJ-02-44the National Natural Science Foundation of China 81871118
6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is a major diabetes complication lacking effective dietary therapies. While amino-acid-targeted diets modulate metabolic health, their impact on renal outcomes via gut microbiota-derived metabolites remains unclear. Here, we investigated whether a 13-week methionine-restricted (MR) diet improves renal outcomes in db/db mice and alters gut-derived short-chain fatty acids (SCFAs) and their receptors. MR improved renal function and histopathology, restored colonic barrier markers (Claudin-1, ZO-1, MUC2), and reduced circulating endotoxin (LPS). 16S rRNA profiling revealed MR-induced gut microbiota remodeling, enriching SCFA-producing taxa like Clostridium spp. This coincided with increased fecal propionate and restored colonic propionate receptor GPR41 expression. Furthermore, fecal propionate and its associated taxa correlated positively with barrier integrity and negatively with systemic LPS, renal TLR4/JNK activation, inflammation, and oxidative stress. Collectively, MR confers renoprotection in db/db mice by modulating the gut-kidney axis via microbiota remodeling and enhanced propionate-GPR41 signaling, highlighting MR as a promising nutritional strategy for DKD management.

Identifiers

PMID42173918
PMCPMC13473145

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.