Evidence map›Paper›PMID 42173893›Full record

ArticleNature communications2026

A transparent PVA-based polymer sunscreen protects retinal tissue from ultraviolet damage.

Siyu Pan, Sa Du, Zeyu Ma, Zhuoyuan Lin, Qiang Zeng, Yen Wei, Bo Wang, Yuwei Wu, Lei Tao

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siyu PanThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China.
Sa DuThe Second Dental Center, National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, PR China.
Zeyu MaThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China.
Zhuoyuan LinThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China.
Qiang ZengThe Second Dental Center, National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, PR China.
Yen WeiThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China.ORCID http://orcid.org/0000-0001-5950-0163
Bo WangInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, PR China. youxihema@gmail.com.
Yuwei WuThe Second Dental Center, National Engineering Laboratory for Digital and Material Technology of Stomatology, Peking University School and Hospital of Stomatology, Beijing, PR China. yuweiwu@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-6818-5406
Lei TaoThe Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, PR China. leitao@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-1735-6586

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22471140
6 · The paper itself

Abstract

Ultraviolet (UV) light causes many eye diseases. Wearing sunglasses blocks <50% UV light from entering eyes. Skin sunscreens are banned for eye use due to irritation and safety concerns. Few sunscreens can be used in the eye to block UV light without compromising the eye functions. Herein, we modified poly(vinyl alcohol) (PVA), the active ingredient in commercial artificial tears, using naturally extracted aldehydes through Hantzsch's reaction and obtained a PVA-syringaldehyde derivative that has a high sun protection factor (SPF 80), excellent UV resistance (>99%) and high transparency (84%) at 1 wt% in water, and a long half-life with little acute irritation and long-term safety when applied to female mouse eyes. Zebrafish protected by this polymer maintained healthy eye tissues and vision-guided behaviors after UV exposure. Polymer treatment on mice eyes effectively protected the retina from UV-induced damage, suggesting its potential as an eye sunscreen.

Indexed as

Polyvinyl AlcoholRetinaSunscreening AgentsUltraviolet RaysAnimalsFemaleMicePolymersSun Protection FactorZebrafishPolymersPolyvinyl AlcoholSunscreening Agents

Identifiers

PMID42173893
PMCPMC13385926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.