Evidence map›Paper›PMID 42173883›Full record

ArticleNature communications2026

TRIM21 facilitates inflammasome assembly and contributes to autoinflammatory disease.

Jessica Carriere, Chawon Yun, Sonal Khare, Sana Ismaeel, Elisabeth Jäger, Vinicius Dantas Martins, Kaiden A Sims, Lan H Chu, Huyen Nguyen, Lucia de Almeida and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jessica CarriereDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA. jessica.carriere@csmc.edu.
Chawon YunDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0046-4732
Sonal KhareDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Sana IsmaeelDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Elisabeth JägerDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-7342-3459
Vinicius Dantas MartinsDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9994-5212
Kaiden A SimsDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0006-5236-3032
Lan H ChuDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Huyen NguyenDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6999-3544
Lucia de AlmeidaDivision of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Janset OnyuruDepartment of Pediatrics, University of California San Diego and Rady Children's Hospital, La Jolla, CA, USA.
Justin RuizDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0112-9928
Hemisha KhatriDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Savita DeviDepartment of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Jae Jin ChaeNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0719-4349
Daniel L KastnerNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-7188-4550
Lori BroderickDepartment of Pediatrics, University of California San Diego and Rady Children's Hospital, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6147-7097
Hal M HoffmanDepartment of Pediatrics, University of California San Diego and Rady Children's Hospital, La Jolla, CA, USA.
Andrea Dorfleutner *Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA. andrea.dorfleutner@csmc.edu.
Christian Stehlik *Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA. christian.stehlik@csmc.edu.ORCID http://orcid.org/0000-0002-3782-2484

Funding

A novel mechanism for NLRP3 inflammasome activation in human macrophagesR01AI165797 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2022 to 2025
$3.8M
CARD-only protein regulation of cytosolic Pattern Recognition Receptor signalingR01AI140702 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DORFLEUTNER, ANDREA, STEHLIK, CHRISTIAN · 2018 to 2022
$2.9M
POP3 regulates type I interferon and ameliorates intestinal inflammationR01DK143393 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Andrea Dorfleutner, Christian Stehlik · 2025 to 2026
$1.5M
A novel protective role of PYDC5 in colorectal cancerR01CA301129 · NCI · CEDARS-SINAI MEDICAL CENTER · PI Andrea Dorfleutner, Christian Stehlik · 2026 to 2026
$679k
American Cancer Society (American Cancer Society, Inc.) PF-23-1149877-01-IBCDAmerican Heart Association (American Heart Association, Inc.) 15PRE25700116American Heart Association (American Heart Association, Inc.) 18CDA34110296American Heart Association (American Heart Association, Inc.) 25POST1374216American Heart Association (American Heart Association, Inc.) 26CDA1588880American Heart Association (American Heart Association, Inc.) 26POST1558214American Heart Association (American Heart Association, Inc.) 834502NCI NIH HHS R01 CA301129NIAID NIH HHS R01 AI140702NIAID NIH HHS R01 AI165797NIDDK NIH HHS R01 DK143393U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA301129U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI140702U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI165797U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK143393
6 · The paper itself

Abstract

Inflammasomes are cytosolic multiprotein complexes facilitating the maturation and release of the inflammatory cytokines interleukin (IL)-1β and IL-18 and pyroptosis. ASC (apoptosis-associated-speck-like protein containing a CARD) is the central inflammasome adaptor. ASC polymerization is crucial for inflammasome assembly, and ASC particle release propagates inflammasome responses to bystander cells. However, control of inflammasome and ASC particle assembly to limit chronic inflammation and the emergence of autoinflammatory diseases is still incompletely understood. Here, we show that the E3 ubiquitin ligase TRIM (tripartite-motif-containing protein) 21, a common autoantigen in autoimmune diseases, is involved in inflammasome assembly. Specifically, TRIM21 binds to and ubiquitinates ASC to facilitate ASC/NLRP3 interactions, ASC polymerization and the release of ASC/TRIM21-containing particles during pyroptosis in human and mouse macrophages. Furthermore, we detect systemic ASC/TRIM21 particles and autoantibodies in human and mouse autoinflammatory disease. Thus, our findings highlight a previously unrecognized role of TRIM21 as an inflammasome component and driver of autoinflammation.

Indexed as

InflammasomesRibonucleoproteinsAnimalsAutoantibodiesCARD Signaling Adaptor ProteinsHEK293 CellsHumansInflammationInterleukin-1betaMacrophagesMiceMice, Inbred C57BLMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisSS-A AntigenAutoantibodiesCARD Signaling Adaptor ProteinsInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPYCARD protein, humanPycard protein, mouseRibonucleoproteinsSS-A AntigenTRIM21 Protein

Identifiers

PMID42173883
PMCPMC13385917

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.