Evidence map›Paper›PMID 42173877›Full record

ArticleNature communications2026

Manganese enhances macrophage bactericidal activity in mice with Staphylococcus aureus osteomyelitis via Sirt3-mitophagy axis.

Xin Guan, Bingsheng Yang, Bowen Bai, Naiqian Cui, Muqi Wang, Jianwen Su, Xiaohu Wu, Chenghua Zhang, Hui Dai, Peng Zhao and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin Guan *Pingshan Hospital, Southern Medical University, Shenzhen, China.ORCID http://orcid.org/0000-0001-7998-6877
Bingsheng Yang *Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0002-1962-4337
Bowen Bai *Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Naiqian CuiGuangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Muqi WangGuangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianwen SuGuangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaohu WuDepartment of Orthopedic Trauma and Arthroplasty, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, China.
Chenghua ZhangGuangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hui DaiGanzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, China.
Peng ZhaoSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. smuzp@smu.edu.cn.ORCID http://orcid.org/0000-0003-4377-1035
Bin YuPingshan Hospital, Southern Medical University, Shenzhen, China. 81297810@qq.com.ORCID http://orcid.org/0009-0005-2890-5922
Bowei WangDepartment of Trauma Emergency Center, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, China. hellobowei@hotmail.com.ORCID http://orcid.org/0000-0002-6914-0605

Funding

Natural Science Foundation of Jiangxi Province (Jiangxi Province Natural Science Foundation) 20253BAC280040
6 · The paper itself

Abstract

Staphylococcus aureus (S. aureus)-induced osteomyelitis remains challenging in clinical practice, wherein macrophages with impaired bactericidal function serve as reservoirs for intracellular bacterial survival, contributing to persistent and relapsing infections. Here, we show that exogenous manganese (Mn

Indexed as

MacrophagesManganeseOsteomyelitisSirtuin 3Staphylococcal InfectionsStaphylococcus aureusAnimalsAnti-Bacterial AgentsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMitochondriaReactive Oxygen SpeciesAnti-Bacterial AgentsManganeseReactive Oxygen SpeciesSirt3 protein, mouseSirtuin 3

Identifiers

PMID42173877
PMCPMC13385904

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.